中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
12期
1587-1589
,共3页
胃肿瘤%生存素%磷酸酶基因
胃腫瘤%生存素%燐痠酶基因
위종류%생존소%린산매기인
Stomach neoplasms%Survivin%Phosphatase gene
目的 探讨生存素(Survivin)和磷酸酶基因(PETN)与胃癌的关系及两者的相关性.方法 采用免疫组化的方法检测105例胃癌病理标本中Survivin、PETN的表达情况,并与98例阴性胃黏膜组织中Sur-vivin、PETN的表达情况比较.结果 胃癌组织标本中Survivin表达阳性率为82.9%(87/105),非胃癌组织标本中Survivin表达阳性率为6.1%(6/98),两者差异有统计学意义(P<0.01);胃癌组织标本中PETN表达阳性率为34.3%(36/105),非胃癌组织标本中PETN表达阳性率为99.0%(97/98),两者差异有统计学意义(P<0.01).胃癌组织中Survivin、PETN的表达与患者的性别无关(P>0.05),而与肿瘤细胞分化程度、浸润深度、淋巴结转移、远处脏器转移及TNM分期有关(P<0.05).Survivin与PETN呈负相关(r=-0.23.P<0.05).结论 胃癌的发生与Survivin的异常高水平表达及PTEN的表达缺失有关;胃癌组织中Survivin、PEIN的表达情况与患者的性别无关,而与肿瘤细胞的分化程度、浸润深度、淋巴结转移、远处脏器转移及TNM分期有关;Survivin与PETN的表达呈负相关关系.
目的 探討生存素(Survivin)和燐痠酶基因(PETN)與胃癌的關繫及兩者的相關性.方法 採用免疫組化的方法檢測105例胃癌病理標本中Survivin、PETN的錶達情況,併與98例陰性胃黏膜組織中Sur-vivin、PETN的錶達情況比較.結果 胃癌組織標本中Survivin錶達暘性率為82.9%(87/105),非胃癌組織標本中Survivin錶達暘性率為6.1%(6/98),兩者差異有統計學意義(P<0.01);胃癌組織標本中PETN錶達暘性率為34.3%(36/105),非胃癌組織標本中PETN錶達暘性率為99.0%(97/98),兩者差異有統計學意義(P<0.01).胃癌組織中Survivin、PETN的錶達與患者的性彆無關(P>0.05),而與腫瘤細胞分化程度、浸潤深度、淋巴結轉移、遠處髒器轉移及TNM分期有關(P<0.05).Survivin與PETN呈負相關(r=-0.23.P<0.05).結論 胃癌的髮生與Survivin的異常高水平錶達及PTEN的錶達缺失有關;胃癌組織中Survivin、PEIN的錶達情況與患者的性彆無關,而與腫瘤細胞的分化程度、浸潤深度、淋巴結轉移、遠處髒器轉移及TNM分期有關;Survivin與PETN的錶達呈負相關關繫.
목적 탐토생존소(Survivin)화린산매기인(PETN)여위암적관계급량자적상관성.방법 채용면역조화적방법검측105례위암병리표본중Survivin、PETN적표체정황,병여98례음성위점막조직중Sur-vivin、PETN적표체정황비교.결과 위암조직표본중Survivin표체양성솔위82.9%(87/105),비위암조직표본중Survivin표체양성솔위6.1%(6/98),량자차이유통계학의의(P<0.01);위암조직표본중PETN표체양성솔위34.3%(36/105),비위암조직표본중PETN표체양성솔위99.0%(97/98),량자차이유통계학의의(P<0.01).위암조직중Survivin、PETN적표체여환자적성별무관(P>0.05),이여종류세포분화정도、침윤심도、림파결전이、원처장기전이급TNM분기유관(P<0.05).Survivin여PETN정부상관(r=-0.23.P<0.05).결론 위암적발생여Survivin적이상고수평표체급PTEN적표체결실유관;위암조직중Survivin、PEIN적표체정황여환자적성별무관,이여종류세포적분화정도、침윤심도、림파결전이、원처장기전이급TNM분기유관;Survivin여PETN적표체정부상관관계.
Objective To explore the significance of Survivin and PTEN in gastric cancer development and correlation between Survivin and PTEN.Methods Immunohistochemical methods were applied to detect the expres.sion of Survivin and PTEN in 105 pathological specimens of gastric cancer, in comparison to that in 98 negative gastric mucosa tissues.Results The positive rate of Survivin expression was 82.9% (87/105) in tissue specimens of gastric cancer and 6.1% (6/98) in tissue specimens of non-gastric cancer;The difference between them was statistically sig nificant (P <0.01).The positive rates of PTEN expression were 34.3% (36/105) in tissue specimens of gastric canc-er and 99.0% (97/98) in tissue specimens of non-gastric cancer;The difference between them was statistically signifi-cant ( P <0.01).The expression of Survivin and PTEN in tissues of gastric cancer had nothing to do with the gender of patients ( P > 0.05 ) , but was correlated with the degree of tumor cell differentiation, depth of invasion, lymph node me-tastasis, distant organ metastasis and TNM staging(P <0.05).Analysis by Spearman showed that Survivin was nega-tively correlated with PTEN( r = -0.23 ,P < 0.05 ).Conclusion The incidence of gastric cancer was related to the abnormally high level of Survivin expression and absence of PTEN expression;The expression of Survivin and PTEN in tissues of gastric cancer was unrelated with the gender of patients, but related to the degree of tumor cell differentia-tion, depth of invasion,lymph node metastasis,distant organ metastasis and TNM staging.The expression of Survivin was negatively correlated with the expression of PTEN.
