CAJ | 학술논문

目的探讨肝血管瘤和肝癌行肝切除术后的血清高尔基体蛋白73(Golgi membrane protein 73,GP73)变化趋势及其与肝癌复发、患者预后生存间的联系.方法采用Western blot定量测定61例手术切除的肝血管瘤和65例肝癌患者术前、术后GP73,并在肝癌组患者中临床诊断肝癌复发时监测GP73变化.结合患者的临床资料及生存预后观察GP73能否作为判断预后的指标.结果肝血管瘤患者术前及术后各时间点间GP73值差异无统计学意义.肝癌组患者术前GP73值为9.9(3.7～15.8) RU,术后3、7、14 d GP73值分别为9.1(3.4～13.3) RU,4.3(1.7 ～9.0)RU,3.3(2.1 ～5.4)RU,各时间点间比较差异有统计学意义(F =72.606,P＜0.001).肝癌组患者中21例复发,复发者术前GP73值为9.9(2.9 ～ 15.0)RU,复发时GP73值为11.0(8.4～ 13.8) RU,两者间差异无统计学意义(Z=1.185,P＞0.05).未复发肝癌44例,术前GP73值为10.5(3.9 ～16.1)RU,与复发者相比差异无统计学意义(Z=-1.546,P＞1.05).结论肝癌切除导致GP73的下降,肝癌复发伴随着GP73水平上升,GP73可以作为肝癌术后复发的监测指标.
목적 탐토간혈관류화간암행간절제술후적혈청고이기체단백73(Golgi membrane protein 73,GP73)변화추세급기여간암복발、환자예후생존간적련계.방법 채용Western blot정량측정61례수술절제적간혈관류화65례간암환자술전、술후GP73,병재간암조환자중림상진단간암복발시감측GP73변화.결합환자적림상자료급생존예후관찰GP73능부작위판단예후적지표.결과 간혈관류환자술전급술후각시간점간GP73치차이무통계학의의.간암조환자술전GP73치위9.9(3.7～15.8) RU,술후3、7、14 d GP73치분별위9.1(3.4～13.3) RU,4.3(1.7 ～9.0)RU,3.3(2.1 ～5.4)RU,각시간점간비교차이유통계학의의(F =72.606,P＜0.001).간암조환자중21례복발,복발자술전GP73치위9.9(2.9 ～ 15.0)RU,복발시GP73치위11.0(8.4～ 13.8) RU,량자간차이무통계학의의(Z=1.185,P＞0.05).미복발간암44례,술전GP73치위10.5(3.9 ～16.1)RU,여복발자상비차이무통계학의의(Z=-1.546,P＞1.05).결론 간암절제도치GP73적하강,간암복발반수착GP73수평상승,GP73가이작위간암술후복발적감측지표.
Objective To investigate changes of GP73 after hepatectomy and its correlations with hepatocellular carcinoma (HCC) recurrence. Methods Perioperative serum GP73 was monitored in hepatic hemangioma and HCC patients undergoing hepatectomy. Clinicopathologic features and follow-up results were collected to evaluate the relationship between serum GP73 level and patients' prognosis.Results There was no statistical difference between preoperative GP73 and postoperative GP73 in hepatic hemangioma group.While preoperative GP73 in HCC group was 9.9(3.7 - 15.8) relative unit (RU),and that on POD3 (postoperative day 3 ) was 9.1 ( 3.4 - 13.3 ) RU,on POD7 was 74.3 ( 1.7 - 9.0) RU,on POD14 was 3.3(2.1 -5.4) RU ( F =72.606,P ＜ 0.001 ).HCC recurred in 21 cases during follow-up,GP73 in recurrent cases [ 11.0 (8.4 - 13.8 ) RU ] was significantly higher than postoperative trough values while it was not different from their preoperative GP73 level [ 9.9 ( 2.9 - 15.0) RU ] ( Z =1.185,P ＞0.05). The preoperative GP73 level between recurrent subgroup and nonrecurrent subgroup was not significantly different (Z =- 1.546,P ＞ 0.05 ).Preoperative GP73 did not correlate to patients' survival.Conclusions Hepatectomy for HCC leads to a significant decrease of GP73 and postoperative HCC recurrence accompanies reelevation of GP73. GP73 could be used as a postoperative monitor for HCC recurrence.