有机化学
有機化學
유궤화학
CHINESE JOURNAL OF ORGANIC CHEMISTRY
2010年
2期
244-249
,共6页
杨德保%刘方明%沈松伟%陈盛钦
楊德保%劉方明%瀋鬆偉%陳盛欽
양덕보%류방명%침송위%진성흠
查尔酮%1,2,4-三唑%1,5-苯并硫氮杂(艹卓)%晶体结构
查爾酮%1,2,4-三唑%1,5-苯併硫氮雜(艸卓)%晶體結構
사이동%1,2,4-삼서%1,5-분병류담잡(초탁)%정체결구
chalcone%1,2,4-triazole%1,5-benzo[b]thiazepine%crystal structure
以α-溴代苯乙酮为原料,在三乙胺作用下制备α-(1,2,4-三唑-1-基)-芳基乙酮(1a～1c),再与芳香醛发生羟醛缩合反应制备相应的含三唑基的查尔酮2a～21,将中间体2a～21同邻氨基硫酚合成新型的2,4-二芳基-3-(1,2,4-三唑-1-基)-2,3-二氢-1,5-苯并硫氮杂(艹卓)(3a～31).所得化合物的结构经元素分析,IR,MS和~1H NMR确认,同时用X射线衍射法测定了化合物2a和3a的晶体结构.
以α-溴代苯乙酮為原料,在三乙胺作用下製備α-(1,2,4-三唑-1-基)-芳基乙酮(1a～1c),再與芳香醛髮生羥醛縮閤反應製備相應的含三唑基的查爾酮2a～21,將中間體2a～21同鄰氨基硫酚閤成新型的2,4-二芳基-3-(1,2,4-三唑-1-基)-2,3-二氫-1,5-苯併硫氮雜(艸卓)(3a～31).所得化閤物的結構經元素分析,IR,MS和~1H NMR確認,同時用X射線衍射法測定瞭化閤物2a和3a的晶體結構.
이α-추대분을동위원료,재삼을알작용하제비α-(1,2,4-삼서-1-기)-방기을동(1a～1c),재여방향철발생간철축합반응제비상응적함삼서기적사이동2a～21,장중간체2a～21동린안기류분합성신형적2,4-이방기-3-(1,2,4-삼서-1-기)-2,3-이경-1,5-분병류담잡(초탁)(3a～31).소득화합물적결구경원소분석,IR,MS화~1H NMR학인,동시용X사선연사법측정료화합물2a화3a적정체결구.
The chalcones 2a～2l were synthesized by aldol condensation reaction of arylaldehydes with 1-aryl-2-(1H-1,2,4-triazol-1-y1)ethanones (1a～1c), which were prepared from 2-bromo-1-arylethanones. Then the intermediates 2a～2l were reacted with 2-aminobenzenethiol to give a series of 3-(1,2,4-triazol-1-y1)-1,5-benzo[b]thiazepine derivatives 3a～31. Compounds 3a～3l were confirmed by means of elemental analysis, IR,~1H NMR, MS techniques, and compounds 2a and 3a were analyzed by X-ray single-crystal diffraction.
