CAJ | 학술논문

肾素-血管紧张素系统( renin-angiotensin system,RAS)在维持血压和体内水盐平衡方面起重要作用.目前的研究提示RAS与肺纤维化、肺动脉高压等多种呼吸系统疾病的发病机制相关,而血管紧张素转换酶-2(angiot ensin-conver ting enzyme-2,ACE2)是ACE同工酶,起负向调节RAS活性的作用,对急性呼吸窘迫综合征等肺部疾病起保护作用,有望成为呼吸系统疾病治疗的新靶点.
신소-혈관긴장소계통( renin-angiotensin system,RAS)재유지혈압화체내수염평형방면기중요작용.목전적연구제시RAS여폐섬유화、폐동맥고압등다충호흡계통질병적발병궤제상관,이혈관긴장소전환매-2(angiot ensin-conver ting enzyme-2,ACE2)시ACE동공매,기부향조절RAS활성적작용,대급성호흡군박종합정등폐부질병기보호작용,유망성위호흡계통질병치료적신파점.
The renin-angiotensin system (RAS) plays a central role in the maintainance of homeostasis of blood pressure and electrolyte balance. Recently,the RAS has been implicated in the pathogenesis on the pathogenesis of respiratory disease,especially in pulmonary fibrosis,pulmonary artery hypertension.Angiotensin-converting enzyme 2 was cloned as a first homolog of human ACE and functioned as an negative regulator of RAS.Recent studies has confirmed the protective effect of ACE2 against acute lung injury.In this review we shall discuss the roles for ACE2 in disease pathogenesis and the possibility of ACE2 as a novel approach for the treatment of lung diseases.