国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2011年
2期
151-154
,共4页
神经生长因子%支气管哮喘%气道炎症%气道高反应性%气道重塑
神經生長因子%支氣管哮喘%氣道炎癥%氣道高反應性%氣道重塑
신경생장인자%지기관효천%기도염증%기도고반응성%기도중소
Nerve growth factor%Bronchial asthma%Airway inflammation%Airway hyperresponsiveness%Airway remodeling
神经生长因子(NGF)是最早发现的神经营养因子之一,来源于多种免疫细胞及肺固有细胞,对多种免疫细胞具有调节作用.近年来研究认为NGF可能在支气管哮喘的发病机制中扮演重要角色.该文综述了NGF的来源细胞及其在调节支气管哮喘的气道炎性反应、气道高反应性及气道重塑中的作用.
神經生長因子(NGF)是最早髮現的神經營養因子之一,來源于多種免疫細胞及肺固有細胞,對多種免疫細胞具有調節作用.近年來研究認為NGF可能在支氣管哮喘的髮病機製中扮縯重要角色.該文綜述瞭NGF的來源細胞及其在調節支氣管哮喘的氣道炎性反應、氣道高反應性及氣道重塑中的作用.
신경생장인자(NGF)시최조발현적신경영양인자지일,래원우다충면역세포급폐고유세포,대다충면역세포구유조절작용.근년래연구인위NGF가능재지기관효천적발병궤제중분연중요각색.해문종술료NGF적래원세포급기재조절지기관효천적기도염성반응、기도고반응성급기도중소중적작용.
The nerve growth factor(NGF) belongs to the neurotrophin family, comes from many immune cells and lung resident cells, and regulates the functions of many immune cells. Recent studies suggest that NGF may play an important role in the pathogenesis of bronchial asthma. In this review, we will provide information about NGF in the airways, describe its expression and regulation, and point out its potential role in inflammation,hyperresponsiveness, and remodelling process observed in asthma.
