CAJ | 학술논문

目的探讨肿瘤转移抑制基因KAI1、基质金属蛋白酶9(MMP-9)在子宫内膜异位症(Endometriosis,EMS;内异症)组织中的表达及意义.方法对本院53例内异症者(研究组)及30例正常子宫内膜者(对照组),应用免疫组化SP法检测不同子宫内膜组织中KAI1及MMP-9的表达,分析两组KAI1及MMP-9表达水平及相关性.结果 KAI1在研究组中呈低表达,而MMP-9呈高表达；KAI1对照组中呈高表达,而MMP-9呈低表达,两组KAI1及MMP-9表达水平比较差异均统计学有意义(P＜0.05).内异症和正常子宫内膜组织中KAI1与MMP-9水平均呈负相关(r=-0.402,-0.550,P＜0.05).结论 KAI1及MMP-9在内异症组织中表达呈负相关,其可能参与了EMS异位内膜的转移和侵袭中作用,促进内异症的发生和发展.可成为EMS预后和复发的监测指标之一.
목적 탐토종류전이억제기인KAI1、기질금속단백매9(MMP-9)재자궁내막이위증(Endometriosis,EMS;내이증)조직중적표체급의의.방법 대본원53례내이증자(연구조)급30례정상자궁내막자(대조조),응용면역조화SP법검측불동자궁내막조직중KAI1급MMP-9적표체,분석량조KAI1급MMP-9표체수평급상관성.결과 KAI1재연구조중정저표체,이MMP-9정고표체；KAI1대조조중정고표체,이MMP-9정저표체,량조KAI1급MMP-9표체수평비교차이균통계학유의의(P＜0.05).내이증화정상자궁내막조직중KAI1여MMP-9수평균정부상관(r=-0.402,-0.550,P＜0.05).결론 KAI1급MMP-9재내이증조직중표체정부상관,기가능삼여료EMS이위내막적전이화침습중작용,촉진내이증적발생화발전.가성위EMS예후화복발적감측지표지일.
Objective To discuss the expression of tumor shift suppressor gene KAI1,matrix metal proteinase 9 (MMP-9) in endometriosis sickness in dystopia internal membrane and its significance.Methods In 53 patients and 30 healthy controls,the expression of KAI1,MMP-9 in the endometriosis was detected with immunohistochemistry SP method,and the relationship was analyzed.Results KAI1 had low expression in EMS patients,while MMP-9 was highly expressed.In the control group,KAI1 was highly expressed while MMP-9 lowly expressed,and the differences between two groups were remarkably significant (P ＜0.05).KAI1 and the MMP-9 expression showed negative correlation between two groups.Conclusions KAI1 and MMP-9 was negatively expressed in EMS,which may play a role in the EMS prognosis.KAI1 and MMP-9 may be served as the prognosis and monitor markers for EMS.