中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
4期
503-504
,共2页
宫颈肿瘤%放疗%化疗%多西他赛%顺铂
宮頸腫瘤%放療%化療%多西他賽%順鉑
궁경종류%방료%화료%다서타새%순박
Cervical cancer%Chemotherapy%Radiotherapy%Docetaxel%Cisplatin
目的 观察多西他赛、顺铂联合同期放疗对中晚期宫颈癌的临床疗效.方法 将64例中晚期宫颈癌患者随机分为两组,对照组32例采用放射治疗,观察组32例在对照组基础上采用多西他赛与顺铂同期化疗.比较两组的临床疗效和不良反应发生情况.结果 观察组总有效率为84.4％,明显高于对照组的59.4％(x2=4.07,P＜0.05).观察组骨髓抑制、恶心呕吐发生率分别为43.8％(14/32)、21.9％(7/32),略高于对照组的31.3％(10/32)、12.5％ (4/32),但差异均无统计学意义(x2=1.09,1.17,均P＞0.05).结论 中晚期宫颈癌采用多西他赛与顺铂同期放化治疗,能够明显提高疗效,并且不会增加不良反应的发生率,值得临床推广应用.
目的 觀察多西他賽、順鉑聯閤同期放療對中晚期宮頸癌的臨床療效.方法 將64例中晚期宮頸癌患者隨機分為兩組,對照組32例採用放射治療,觀察組32例在對照組基礎上採用多西他賽與順鉑同期化療.比較兩組的臨床療效和不良反應髮生情況.結果 觀察組總有效率為84.4％,明顯高于對照組的59.4％(x2=4.07,P＜0.05).觀察組骨髓抑製、噁心嘔吐髮生率分彆為43.8％(14/32)、21.9％(7/32),略高于對照組的31.3％(10/32)、12.5％ (4/32),但差異均無統計學意義(x2=1.09,1.17,均P＞0.05).結論 中晚期宮頸癌採用多西他賽與順鉑同期放化治療,能夠明顯提高療效,併且不會增加不良反應的髮生率,值得臨床推廣應用.
목적 관찰다서타새、순박연합동기방료대중만기궁경암적림상료효.방법 장64례중만기궁경암환자수궤분위량조,대조조32례채용방사치료,관찰조32례재대조조기출상채용다서타새여순박동기화료.비교량조적림상료효화불량반응발생정황.결과 관찰조총유효솔위84.4％,명현고우대조조적59.4％(x2=4.07,P＜0.05).관찰조골수억제、악심구토발생솔분별위43.8％(14/32)、21.9％(7/32),략고우대조조적31.3％(10/32)、12.5％ (4/32),단차이균무통계학의의(x2=1.09,1.17,균P＞0.05).결론 중만기궁경암채용다서타새여순박동기방화치료,능구명현제고료효,병차불회증가불량반응적발생솔,치득림상추엄응용.
Objective To explore the effect of docetaxel,cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer.Methods 64 patients with advanced cervical cancer were randomly divided into two groups,observation group with 32 cases who were treated with docetaxel and cisplatin concurrent chemotherapy and radiotherapy and control group with 32 cases were treated with radiotherapy.The clinical effect and adverse reaction between two groups were compared.Results The total effective rate in observation group was 84.4％,which significantly higher than that in control group of 59.4％ ( x2 =4.07,P ＜0.05 ).There were no significant differences in incidences of bone marrow suppression and nausea and vomiting between two groups(x2 =1.09,1.17,all P ＞0.05).Conclusion Docetaxel,cisplatin combined with concurrent chemotherapy and radiotherapy in the treatment of patients with advanced cervical cancer could enhance clinical effect,and not increase the adverse reaction incidence,which could be applied in clinic.
