中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
15期
8-10
,共3页
手术后恶心呕吐%昂丹司琼%甲氧氯普安%氟哌利多
手術後噁心嘔吐%昂丹司瓊%甲氧氯普安%氟哌利多
수술후악심구토%앙단사경%갑양록보안%불고리다
Postoperative nausea and vomiting%Ondansetron%Metoclopramide%Haloperidol
目的 探讨昂丹司琼、甲氧氯普安和氟哌利多预防神经外科手术后患者恶心呕吐的临床差异.方法 共纳入90例神经外科手术治疗患者,采用随机数字表法分为四组,麻醉诱导后对照组18例给予0.9％氯化钠10ml;昂丹司琼组24例给予昂丹司琼4 mg；甲氧氯普胺组24例给予甲氧氯普胺10 mg;氟哌利多组24例给予氟哌利多2.5 mg.比较各组疗效及不良反应.结果 与对照组比较,昂丹司琼组、甲氧氯普胺组和氟哌利多组均能明显地抑制神经外科手术后恶心呕吐的发生,差异有统计学意义(P＜0.05)；昂丹司琼组总有效率[79.2％(19/24)]明显高于甲氧氯普胺组[58.3％(14/24)]及氟哌利多组[54.2％(13/24)],差异有统计学意义(P＜0.05)；而甲氧氯普胺组与氟哌利多组总有效率比较差异无统计学意义(P＞0.05).甲氧氯普胺组不良反应发生率[ 16.7％(4/24)]与昂丹司琼组[8.3％(2/24)]、氟哌利多组[ 12.5％(3/24)]比较差异无统计学意义(P＞ 0.05).结论 昂丹司琼、甲氧氯普胺和氟哌利多均能明显地抑制神经外科手术后恶心呕吐的发生,且昂丹司琼作用明显好于甲氧氯普胺及氟哌利多.因此对神经外科手术患者术中使用抗恶心呕吐药物是必要的.
目的 探討昂丹司瓊、甲氧氯普安和氟哌利多預防神經外科手術後患者噁心嘔吐的臨床差異.方法 共納入90例神經外科手術治療患者,採用隨機數字錶法分為四組,痳醉誘導後對照組18例給予0.9％氯化鈉10ml;昂丹司瓊組24例給予昂丹司瓊4 mg；甲氧氯普胺組24例給予甲氧氯普胺10 mg;氟哌利多組24例給予氟哌利多2.5 mg.比較各組療效及不良反應.結果 與對照組比較,昂丹司瓊組、甲氧氯普胺組和氟哌利多組均能明顯地抑製神經外科手術後噁心嘔吐的髮生,差異有統計學意義(P＜0.05)；昂丹司瓊組總有效率[79.2％(19/24)]明顯高于甲氧氯普胺組[58.3％(14/24)]及氟哌利多組[54.2％(13/24)],差異有統計學意義(P＜0.05)；而甲氧氯普胺組與氟哌利多組總有效率比較差異無統計學意義(P＞0.05).甲氧氯普胺組不良反應髮生率[ 16.7％(4/24)]與昂丹司瓊組[8.3％(2/24)]、氟哌利多組[ 12.5％(3/24)]比較差異無統計學意義(P＞ 0.05).結論 昂丹司瓊、甲氧氯普胺和氟哌利多均能明顯地抑製神經外科手術後噁心嘔吐的髮生,且昂丹司瓊作用明顯好于甲氧氯普胺及氟哌利多.因此對神經外科手術患者術中使用抗噁心嘔吐藥物是必要的.
목적 탐토앙단사경、갑양록보안화불고리다예방신경외과수술후환자악심구토적림상차이.방법 공납입90례신경외과수술치료환자,채용수궤수자표법분위사조,마취유도후대조조18례급여0.9％록화납10ml;앙단사경조24례급여앙단사경4 mg；갑양록보알조24례급여갑양록보알10 mg;불고리다조24례급여불고리다2.5 mg.비교각조료효급불량반응.결과 여대조조비교,앙단사경조、갑양록보알조화불고리다조균능명현지억제신경외과수술후악심구토적발생,차이유통계학의의(P＜0.05)；앙단사경조총유효솔[79.2％(19/24)]명현고우갑양록보알조[58.3％(14/24)]급불고리다조[54.2％(13/24)],차이유통계학의의(P＜0.05)；이갑양록보알조여불고리다조총유효솔비교차이무통계학의의(P＞0.05).갑양록보알조불량반응발생솔[ 16.7％(4/24)]여앙단사경조[8.3％(2/24)]、불고리다조[ 12.5％(3/24)]비교차이무통계학의의(P＞ 0.05).결론 앙단사경、갑양록보알화불고리다균능명현지억제신경외과수술후악심구토적발생,차앙단사경작용명현호우갑양록보알급불고리다.인차대신경외과수술환자술중사용항악심구토약물시필요적.
Objective To investigate the clinical difference of ondansetron,metoclopramide and haloperidol in the prevention of postoperative nausea and vomiting after neurosurgery.Methods Ninety patients with neurosurgery were divided by random digits table method into four groups:control group ( 18 cases ) treated with 10 ml 0.9％ sodium chloride ;ondansetron group (24 cases ) received ondansetron 4 mg;metoclopramide group (24 cases) with metoclopramide 10 mg and haioperidol group (24 cases) with haloperidol 2.5 mg.The efficacy and adverse reaction were compared among four groups.Results Compared with control group,ondansetron,metoclopramide and haloperidol could obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,the difference had statistical significance (P＜ 0.05).Total effective rate of ondansetron group [79.2％( 19/24)] was significantly higher than that of metoclopramide group [ 58.3％ ( 14/24 ) ] and haloperidol group [ 54.2％ ( 13/24 ) ] (P ＜ 0.05 ).And total effective rate of metoclopramide group and haloperidol group had no significant difference (P ＞ 0.05 ).The occurrence rate of adverse reaction of metoclopramide group [ 16.7％(4/24)] had no statistical significance compared with that of ondansetron group[8.3％(2/24)] and haloperidol group[ 12.5％(3/24)] (P ＞ 0.05).Conclusions Ondansetron,metoclopramide and haloperidol can obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,and the effect of ondansetron is significantly better than that of metoclopramide and haloperidol.Therefore,it is necessary to use drugs for preventing postoperative nausea and vomiting for patients during neurosurgery.
