中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
16期
2169-2170
,共2页
骨关节炎%滑液%白细胞介素1%肿瘤坏死因子α
骨關節炎%滑液%白細胞介素1%腫瘤壞死因子α
골관절염%활액%백세포개소1%종류배사인자α
Osteoarthritis%Synovial fluid%Interleukin-1%Tumor necrosis factor alpha
目的 观察骨性关节炎(OA)患者膝关节液及血清中白细胞介素-1(IL-1)及肿瘤坏死因子-α(TNF-α)水平与病变程度的关系. 方法 50例单侧膝关节OA患者中早期、中期和晚期分别为18例、15例和17例,检测患侧膝关节液及血清中IL-1和TNF-α水平,以健康志愿者15例为对照组. 结果 OA患者膝关节液及血清中IL-1及TNF-α水平高于对照组(P＜0.05),随着疾病程度加重,膝关节液及血清中的IL-1及TNF-α水平显著增加,IL-1和TNF-α水平存在线性相关(均P＜0.01). 结论 IL-1和TNF-α与OA患者免疫炎症有关,其水平高低可反映病情活动变化情况,与病变程度密切相关,联合检测这两种指标有助于病情判断.
目的 觀察骨性關節炎(OA)患者膝關節液及血清中白細胞介素-1(IL-1)及腫瘤壞死因子-α(TNF-α)水平與病變程度的關繫. 方法 50例單側膝關節OA患者中早期、中期和晚期分彆為18例、15例和17例,檢測患側膝關節液及血清中IL-1和TNF-α水平,以健康誌願者15例為對照組. 結果 OA患者膝關節液及血清中IL-1及TNF-α水平高于對照組(P＜0.05),隨著疾病程度加重,膝關節液及血清中的IL-1及TNF-α水平顯著增加,IL-1和TNF-α水平存在線性相關(均P＜0.01). 結論 IL-1和TNF-α與OA患者免疫炎癥有關,其水平高低可反映病情活動變化情況,與病變程度密切相關,聯閤檢測這兩種指標有助于病情判斷.
목적 관찰골성관절염(OA)환자슬관절액급혈청중백세포개소-1(IL-1)급종류배사인자-α(TNF-α)수평여병변정도적관계. 방법 50례단측슬관절OA환자중조기、중기화만기분별위18례、15례화17례,검측환측슬관절액급혈청중IL-1화TNF-α수평,이건강지원자15례위대조조. 결과 OA환자슬관절액급혈청중IL-1급TNF-α수평고우대조조(P＜0.05),수착질병정도가중,슬관절액급혈청중적IL-1급TNF-α수평현저증가,IL-1화TNF-α수평존재선성상관(균P＜0.01). 결론 IL-1화TNF-α여OA환자면역염증유관,기수평고저가반영병정활동변화정황,여병변정도밀절상관,연합검측저량충지표유조우병정판단.
Objective To explore the relationships between the levels of synovial fluid and serum interleukin-1(IL-1)and tumor necrosis factor alpha(TNF-α)and severity of knee osteoarthritis (OA). Methods 50 patients with unilateral OA(18 cases in early stage,15 cases in middle stage,and 17 cases in terminal stage)were included in the study.15 healthy volunteers were examined as the control group.Synovial fluid and serum of all patients and volunteers were collected for measurement of IL-1 and TNF-α. Results The IL-1 and TNF-α levels of synovial fluids and serum in OA group were significantly higher than those of the control group(P <0.01).With the progress of OA,the IL-1 and TNF-α levels were increased significantly(P <0.01).IL-1 level in synovial fluid and serum of OA group was correlated positively with TNF-α level(P <0.01). Conclusion IL-1 and TNF-α were related to OA patients with immune inflammation,and their levels could reflect changes in disease activity.The increasing IL-1 and TNF-α levels in synovial fluids and serum were positively correlated with the progress of OA.Therefore,combined detection of these two indexes could be useful for determining the pathogenetic condition of KOA.
