CAJ | 학술논문

目的通过临床观察阿托伐他汀与银杏叶制剂对颈动脉粥样硬化斑块患者颈动脉超声相关指标及血脂的影响,探讨颈动脉粥样硬化斑块、血脂的药物干预疗效.方法选择经超声检查存在颈动脉粥样硬化斑块的患者206例,然后随机数字表法分为4组,其中对照组50例、阿托伐他汀组52例、银杏叶制剂组53例、阿托伐他汀联合银杏叶制剂组51例.对照组单用西药基础治疗,其他3组在对照组治疗基础上分别加用阿托伐他汀(20 mg,每晚1次)、银杏叶(80 mg,3次/d)、阿托伐他汀联合银杏叶(剂量同前2组),观察治疗前后颈动脉内膜中层厚度(IMT)、斑块面积和血脂的变化,观察时间为6个月.结果阿托伐他汀组、银杏叶制剂组、阿托伐他汀联合银杏叶组颈动脉斑块、血脂定量下降优于对照组,与治疗前及治疗后的对照组有统计学差异,而阿托伐他汀联合银杏叶制剂组颈动脉斑块定量下降最明显,与其他组对比有统计学差异.结论阿托伐他汀、银杏叶均可使颈动脉粥样硬化斑块缩小,IMT变薄,且联合用药效果更明显.
목적 통과림상관찰아탁벌타정여은행협제제대경동맥죽양경화반괴환자경동맥초성상관지표급혈지적영향,탐토경동맥죽양경화반괴、혈지적약물간예료효.방법 선택경초성검사존재경동맥죽양경화반괴적환자206례,연후수궤수자표법분위4조,기중대조조50례、아탁벌타정조52례、은행협제제조53례、아탁벌타정연합은행협제제조51례.대조조단용서약기출치료,기타3조재대조조치료기출상분별가용아탁벌타정(20 mg,매만1차)、은행협(80 mg,3차/d)、아탁벌타정연합은행협(제량동전2조),관찰치료전후경동맥내막중층후도(IMT)、반괴면적화혈지적변화,관찰시간위6개월.결과 아탁벌타정조、은행협제제조、아탁벌타정연합은행협조경동맥반괴、혈지정량하강우우대조조,여치료전급치료후적대조조유통계학차이,이아탁벌타정연합은행협제제조경동맥반괴정량하강최명현,여기타조대비유통계학차이.결론 아탁벌타정、은행협균가사경동맥죽양경화반괴축소,IMT변박,차연합용약효과경명현.
Objectives To observe the influence of Atorvastatin and Ginkgo Biloba Extract (GBE) on the relative carotid ultrasonic indexes and blood lipid in patients with carotid atherosclerotic plaque. Methods A total of 206 cases patients who had been detected the carotid atherosclerotic plaque by ultrasound were divided into 4 groups. There were 50 cases in control group, 52 cases in Atorvastatin group, 53 cases in GBE group and 51 cases in Atorvastatin combined with GBE group. Only western medicine was used for basic treatment in the control group,but Atorvastatin, GBE and Atorvastatin combined with GBE were respectively used in the other three groups. The in-tima-media thickness (IMT) and changes of plaque area and blood lipid in carotid arteries before and after the treat-ment were observed for 6 months. Results The quantitative changes of carotid atherosclerotic plaque and blood fats in Astorvastatin group, GBE group and Atorvastatin combined with GBE group were all lower than those in the con-trol group(P <0.05). Furthermore the quantitative change was mostly significant in the Atorvastatin combined with GBE group(P<0.05). Conclusions Both Atorvastatin and GBE can reduce carotid atherosclerotic plaque. Fur-thermore the combination of two drugs shows high therapeutic effects.