中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
4期
413-414
,共2页
糖尿病,2型%肾病%C肽%尿白蛋白排泄率
糖尿病,2型%腎病%C肽%尿白蛋白排洩率
당뇨병,2형%신병%C태%뇨백단백배설솔
Diabetes mellitus,type 2%Nephrosis%C-peptide%Urinary albumin excretion rate
目的 探讨2型糖尿病肾病患者血清C肽水平变化的意义.方法 选取住院2型糖尿病患者120例,按尿白蛋白排泄率大小分成3组,正常白蛋白尿组34例,微量白蛋白尿组40例,临床白蛋白尿组46例,同时设血糖正常健康组30例.测各组空腹血糖、糖化血红蛋白(HbA1c)、空腹血清C肽(FCP),并进行比较分析.结果 微量白蛋白尿组和临床白蛋白尿组患者血清C肽与正常健康组比较,差异有统计学意义[(1.27±0.5)μg/L和(0.32±0.16)μg/L比(2.39±0.22)μg/L,P＜0.01];血清C肽水平与尿白蛋白排泄率呈负相关(r=-0.745,P＜0.01).结论 血清C肽水平的下降可能参与2型糖尿病肾病发生发展.
目的 探討2型糖尿病腎病患者血清C肽水平變化的意義.方法 選取住院2型糖尿病患者120例,按尿白蛋白排洩率大小分成3組,正常白蛋白尿組34例,微量白蛋白尿組40例,臨床白蛋白尿組46例,同時設血糖正常健康組30例.測各組空腹血糖、糖化血紅蛋白(HbA1c)、空腹血清C肽(FCP),併進行比較分析.結果 微量白蛋白尿組和臨床白蛋白尿組患者血清C肽與正常健康組比較,差異有統計學意義[(1.27±0.5)μg/L和(0.32±0.16)μg/L比(2.39±0.22)μg/L,P＜0.01];血清C肽水平與尿白蛋白排洩率呈負相關(r=-0.745,P＜0.01).結論 血清C肽水平的下降可能參與2型糖尿病腎病髮生髮展.
목적 탐토2형당뇨병신병환자혈청C태수평변화적의의.방법 선취주원2형당뇨병환자120례,안뇨백단백배설솔대소분성3조,정상백단백뇨조34례,미량백단백뇨조40례,림상백단백뇨조46례,동시설혈당정상건강조30례.측각조공복혈당、당화혈홍단백(HbA1c)、공복혈청C태(FCP),병진행비교분석.결과 미량백단백뇨조화림상백단백뇨조환자혈청C태여정상건강조비교,차이유통계학의의[(1.27±0.5)μg/L화(0.32±0.16)μg/L비(2.39±0.22)μg/L,P＜0.01];혈청C태수평여뇨백단백배설솔정부상관(r=-0.745,P＜0.01).결론 혈청C태수평적하강가능삼여2형당뇨병신병발생발전.
Objective To investigate the change of serum C-peptide level in type 2 diabetic nephrosis patients. Methods We recruited 120 patients with type 2 diabetes. The level of fasting plasma glucose (FBG), glycated hemoglobin (HbA1c), fasting C-peptide (FCP) and urinary albumin excretion rate (UAER) were measured.According to UAER, 120 patients were divided into Group Ⅰ: normal albuminuria group, 34 patients; Group Ⅱ:microalbuminuria group, 40 patients; Group Ⅲ: clinical albuminuria, 46 patients. At same time, we selected 30 healthy people as control group. Results The level of C-peptide decreased significantly in Group Ⅱ and Group Ⅲ compared with that of control group (P ＜0.01 ). The difference of C-peptide level between Group Ⅱ, Group Ⅳ and Group Ⅰ was statistically significant (P ＜ 0.01 ). The level of C-Peptide and urinary albumin excretion rate was negatively correlated (R = -0. 745 ,P ＜ 0. 01 ). Conclusion The decline of serum C-pcptide may be involved in the development of type 2 diabetic nephropathy.
