CAJ | 학술논문

目的:观察七叶心康胶囊是否有心血管方面的药理活性作用,为进一步开发三七茎叶提供依据.方法:采用七叶心康胶囊对氯仿诱导小鼠心律失常动物模型、乌头碱诱导大鼠心律失常动物模型、异丙肾上腺素诱导大鼠急性心肌缺血的动物模型和七叶心康胶囊对大鼠体耳部血流灌注和血液粘度的影响等实验研究来观察七叶心康胶囊对心血管方面的药理活性.结果:实验表明七叶心康胶囊对对氯仿诱导小鼠心律失常模型动物、乌头碱诱导大鼠心律失常模型和异丙肾上腺素诱导大鼠急性心肌缺血模型动物均有保护作用;七叶心康胶囊具有提高正常大鼠耳部血流量,降低正常大鼠全血的血液粘度.结论:七叶心康胶囊在心血管方面具有较强的药理活性,值得作进一步的研究和开发.
목적:관찰칠협심강효낭시부유심혈관방면적약리활성작용,위진일보개발삼칠경협제공의거.방법:채용칠협심강효낭대록방유도소서심률실상동물모형、오두감유도대서심률실상동물모형、이병신상선소유도대서급성심기결혈적동물모형화칠협심강효낭대대서체이부혈류관주화혈액점도적영향등실험연구래관찰칠협심강효낭대심혈관방면적약리활성.결과:실험표명칠협심강효낭대대록방유도소서심률실상모형동물、오두감유도대서심률실상모형화이병신상선소유도대서급성심기결혈모형동물균유보호작용;칠협심강효낭구유제고정상대서이부혈류량,강저정상대서전혈적혈액점도.결론:칠협심강효낭재심혈관방면구유교강적약리활성,치득작진일보적연구화개발.
Objective: To observe the protective effect of Qiyexinkang capsule on arrhythmia mice models through experiment to prove the pharmacological activity functions of Qiyexinkang capsule for cardiovascular and provide the basis for the further development of stem and leaf of Panax notoginseng. Methods: A chloroform-induced arrhythmia mice model, an aconitine-induced arrhythmia rat model and an isoproterenol-induced acute myocardial ischemia rat model were made to test the effect of Qiyexinkang capsule on the ear blood perfusion of rats and their blood viscosity so as to select the pharmacological activity functions of Qiyexinkang capsule for cardiovascular. Results: Qiyexinkang capsule showed an obvious protective effect on the chloroform-induced arrhythmia mice, aconitine-induced arrhythmia rats and isoproterenol-induced acute myocardial ischemia arrhythmia rats and could greatly improve the blood flow of the ears of the test mice and lower the blood viscosity of the normal rats. Conclusion: Qiyexinkang capsule has a strong pharmacological activity for the cardiovascular and is worth studying and developing further.