CAJ | 학술논문

RNA沉默是一种由双链RNA诱导同源RNA降解的现象,是植物的一种天然抗病毒机制.但是由于长期的共进化过程,一些病毒会在siRNA沉默途径以及miRNA沉默途径中编码一些抑制蛋白来对抗这种机制,使其作用受到抑制.文章对RNA沉默的发现、过程、抑制及其由RNA沉默介导的对RNA病毒、DNA病毒的抗性、以及由转病毒基因介导的病毒抗性等几种植物抗病机制.同时,对研究中所存在的一些问题作了分析,并就今后的研究重点和方向作了展望.
RNA침묵시일충유쌍련RNA유도동원RNA강해적현상,시식물적일충천연항병독궤제.단시유우장기적공진화과정,일사병독회재siRNA침묵도경이급miRNA침묵도경중편마일사억제단백래대항저충궤제,사기작용수도억제.문장대RNA침묵적발현、과정、억제급기유RNA침묵개도적대RNA병독、DNA병독적항성、이급유전병독기인개도적병독항성등궤충식물항병궤제.동시,대연구중소존재적일사문제작료분석,병취금후적연구중점화방향작료전망.
RNA silencing is a phenomenon of homologous RNA degradation induced by dsRNA,which works as a natural virus-resistant mechanism in plant. However,in the long co-evolution progress,a number of inhibitory proteins coded by virus in the proeess of siRNA or miRNA silencing could antagonize and inhibit this mechanism. The discovery,proeess and inhibition of RNA silencing,as well as the research advances in plant virus-resistance induced by RNA silencing were reviewed. Several plant disease-resistance mechanism were discussed,inclulding the resistance of RNA viruses and DNA viruses mediated by RNA silencing and the virus resistance mediated by virus transgenes. Meanwhile,the problems existed in the research were properly analyzed,and the key points and the research directions of future prospect were discussed.