南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2010年
2期
388-390
,共3页
不育症%染色体核型%Y染色体微缺失%精索静脉曲张%男性
不育癥%染色體覈型%Y染色體微缺失%精索靜脈麯張%男性
불육증%염색체핵형%Y염색체미결실%정색정맥곡장%남성
infertility%chromosome karyotype%Y chromosome microdeletion%varicocele%male
目的 探讨染色体核型异常及Y染色体微缺失与男性原发不育的关系.方法 利用染色体技术、PCR技术等对133例男性不育患者进行外周血染色体分析及Y染色体微缺失检测.结果 133例男性原发不育患者中发现异常核型25例(18.80%);发现Y染色体微缺失12例(9.02%),其中2例精索静脉曲张及2例隐睾患者;4人同时存在染色体核型异常及Y染色体微缺失.结论男性原发不育与染色体核型异常及Y染色体微缺失关系密切,对男性原发不育患者进行染色体核型及Y染色体微缺失检测非常重要.
目的 探討染色體覈型異常及Y染色體微缺失與男性原髮不育的關繫.方法 利用染色體技術、PCR技術等對133例男性不育患者進行外週血染色體分析及Y染色體微缺失檢測.結果 133例男性原髮不育患者中髮現異常覈型25例(18.80%);髮現Y染色體微缺失12例(9.02%),其中2例精索靜脈麯張及2例隱睪患者;4人同時存在染色體覈型異常及Y染色體微缺失.結論男性原髮不育與染色體覈型異常及Y染色體微缺失關繫密切,對男性原髮不育患者進行染色體覈型及Y染色體微缺失檢測非常重要.
목적 탐토염색체핵형이상급Y염색체미결실여남성원발불육적관계.방법 이용염색체기술、PCR기술등대133례남성불육환자진행외주혈염색체분석급Y염색체미결실검측.결과 133례남성원발불육환자중발현이상핵형25례(18.80%);발현Y염색체미결실12례(9.02%),기중2례정색정맥곡장급2례은고환자;4인동시존재염색체핵형이상급Y염색체미결실.결론남성원발불육여염색체핵형이상급Y염색체미결실관계밀절,대남성원발불육환자진행염색체핵형급Y염색체미결실검측비상중요.
Objective To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients. Methods Karyotypic anlaysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis. Results Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.Conclusion The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.
