CAJ | 학술논문

目的探讨彩色多普勒超声在强直性脊柱炎(AS)患者骶髂关节炎疗效评估中的价值.方法对比30例健康志愿者和50例AS患者骶髂关节的彩色多普勒高频声像和血流情况及AS患者用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白质注射剂治疗前、后骶髂关节高频声像和血流的改变,并将治疗前后的血沉、C反应蛋白和毕氏AS活动指数(BASDAI)、功能指数(BASFI)等作对比分析.结果与健康志愿者比较AS患者骶髂关节超声检查阳性率差异有显著性意义(P＜0.05)；治疗前骶髂关节血流阻力指数为0.57±0.09:治疗12周和24周后超声检查阳性率均较治疗前有明显下降(P＜0.05)；治疗后12周及24周骶髂关节血流阻力指数分别为0.65±0.08、0.63±0.05,与治疗前比较差异有统计学意义(P＜0.05).治疗前、治疗后12周和24周比较,患者BASDAI、BASFI、血沉、C反应蛋白差异均有显著性(P＜0.05).结论彩色多普勒超声能敏感地发现骶髂关节病变的变化情况,可作为这些软组织病变的常规监测手段,并可用于AS患者病情的追踪和临床疗效的评价.
목적 탐토채색다보륵초성재강직성척주염(AS)환자저가관절염료효평고중적개치.방법 대비30례건강지원자화50례AS환자저가관절적채색다보륵고빈성상화혈류정황급AS환자용중조인Ⅱ형종류배사인자수체-항체융합단백질주사제치료전、후저가관절고빈성상화혈류적개변,병장치료전후적혈침、C반응단백화필씨AS활동지수(BASDAI)、공능지수(BASFI)등작대비분석.결과 여건강지원자비교AS환자저가관절초성검사양성솔차이유현저성의의(P＜0.05)；치료전저가관절혈류조력지수위0.57±0.09:치료12주화24주후초성검사양성솔균교치료전유명현하강(P＜0.05)；치료후12주급24주저가관절혈류조력지수분별위0.65±0.08、0.63±0.05,여치료전비교차이유통계학의의(P＜0.05).치료전、치료후12주화24주비교,환자BASDAI、BASFI、혈침、C반응단백차이균유현저성(P＜0.05).결론 채색다보륵초성능민감지발현저가관절병변적변화정황,가작위저사연조직병변적상규감측수단,병가용우AS환자병정적추종화림상료효적평개.
Objective To explore the value of color Doppler ultrasound in evaluating therapeutic effects on sacroiliitis in ankylosing spondylitis (AS) patients.Methods Color Doppler high-frequency ultrasound imagos and blood flow in 30 healthy volunteers and 50 AS patients,changes of high-frequency ultrasound images and blood flow of the involved sites in AS patients pre-and after-Etanercept treatments,as well as erythrocyte sedimentation rate,Creactive protein,and the Bath ankylosing spondylitis disease activity indices pre- and after treatments were compared.Results Positive rates of sacroiliac joints were significantly different between healthy volunteers and AS patients by ultrasonograph(P ＜ 0.05 ).Resistance index in AS patients' sacroiliac joints was 0.57 ± 0.09 before treatment.Positive rates by ultrasonograph were significantly decreased at both 12 weeks and 24 weeks after treatment compared to that before treatment( P ＜ 0.05).Resistance index in AS patients' sacroiliac joints were 0.65 ± 0.08 and 0.63 ±0.05 after treatment 12,24 weeks of Etunereept treatment;there was significant difference for patient's BASDAI,BASFI,erythrocyte sedimentation rate,and C-reactive protein before treatment and 12 weeks and 24 weeks after treatment(P ＜0.05).Conclusions Ultrasound can sensitively detect pathological changes of joint synovium,thus it may be used as routine methods for monitoring diseases,and used to follow up AS patients and evaluate clinical efficacy