CAJ | 학술논문

目的研究pH对左旋布比卡因(levobupivacaine,LEVO)肌间沟臂丛神经阻滞药代动力学的影响.方法 20例择期上肢手术患者,ASA Ⅰ～Ⅱ级.按随机数字表法随机分为两组,Ⅰ组(对照组)和Ⅱ组(试验组),分别用0.375%LEVO及其碱化液行肌间沟入路臂丛神经阻滞.于注药前及注药后10、20、30、45、60、90、120、180、240、360、480、720 min采血,高效液相色谱法测定LJEVO血药浓度.结果两组患者的血药浓度-时间数据经3P97软件进行曲线拟合和模型识别,均符合二房室开放模型.主要药代动力学参数t1/2β、Tmax、Cmax分别为(4.58±0.66)、(4.22±0.37)h;(0.31±0.19)、(0.26±0.18)h和(0.989±0.273)、(1.149±0.317)mg/L.结论 LEVO碱化后行臂丛神经阻滞血药浓度升高,但其药代动力学没有发生明显变化.
목적 연구pH대좌선포비잡인(levobupivacaine,LEVO)기간구비총신경조체약대동역학적영향.방법 20례택기상지수술환자,ASA Ⅰ～Ⅱ급.안수궤수자표법수궤분위량조,Ⅰ조(대조조)화Ⅱ조(시험조),분별용0.375%LEVO급기감화액행기간구입로비총신경조체.우주약전급주약후10、20、30、45、60、90、120、180、240、360、480、720 min채혈,고효액상색보법측정LJEVO혈약농도.결과 량조환자적혈약농도-시간수거경3P97연건진행곡선의합화모형식별,균부합이방실개방모형.주요약대동역학삼수t1/2β、Tmax、Cmax분별위(4.58±0.66)、(4.22±0.37)h;(0.31±0.19)、(0.26±0.18)h화(0.989±0.273)、(1.149±0.317)mg/L.결론 LEVO감화후행비총신경조체혈약농도승고,단기약대동역학몰유발생명현변화.
Objective To evaluate the pharmacokinetics of alkalinized levobupivacaine (LEVO) for interscalene brachial plexus block.Methods 20 patients,ASA Ⅰ～Ⅱ ,undergoing elective upper shoulder surgery were injected hydrochloride or alkalinized LEVO for interscalene brachial plexus block. Venous blood were collected for assay of the total plasma concentration of LEVO immediately before interscalene administration and 10,20,30,45,60,90,120,180,240,360,480,720 min after injection.Blood samples were measured by high-performance liquid chromatography.Results The concentration- time curves in two groups were both adequately in line with a two-compartment open model after the curve and model fitting by 3P97 software package.The main pharmacokinetic parameter such as t1/2β,Tmax,Cmax was (4.58±0.66),(4.22±0.37)h; ( 0.31 ±0. 19 ),(0.26±0.18)h and (0.989±0.273),(1.149 ±0.317)mg/L,respectively.Conclusion The plasma concentration of LEVO is decreased after alkalinized,while its pharmacokinetics does not change.