国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
5期
513-516
,共4页
内皮祖细胞%CD34~+%Framingham心血管危险因素积分%高血压病%血管功能
內皮祖細胞%CD34~+%Framingham心血管危險因素積分%高血壓病%血管功能
내피조세포%CD34~+%Framingham심혈관위험인소적분%고혈압병%혈관공능
Endothelial progenitor cells%CD34~+%Framingham risk factors Score%Hypertension%Vascular function
目的 探讨能否根据外周血内皮祖细胞(endothelial progenitor cells,EPCs)CD34~+水平评价高血压病患者动脉血管病变程度.方法 高血压病患者组62例,对照组20例.高血压病患者采用Framingham心血管危险阂素积分分层心血管危险因素,分为低危组18例,中危组14例,高危组17例,极高危组13例.作外周血循环EPCs CD34~+水平、内皮依赖性血管舒张功能(flow-mediated dialation,FMD)测定并作EPCs CD34~+水平与Framingham心血管危险因素积分、FMD的相关性分析.结果 高血压病患者外周循环EPCs CD34~+水平随着其心血管危险程度的增加.逐步下降,各组间比较[1]差异均有显著性(P<0.05).高血压病患者肱动脉FMD随着其心血管危险程度的增加显著下降(P<0.01).各研究组高血压病患者循环EPCs CD34~+水平与Framingham心血管危险因素积分呈负相关(r=-0.875,P<0.01),与肱动脉FMD呈正相关(r=0.859,P<0.01).结论 高血压病患者循环EPCs CD34~+水平下降与心血管危险因素、动脉血管功能损伤有显著的相关性.说明循环EPCs CD34~+水平可以作为评价高血压病患者动脉血管病变的指标.
目的 探討能否根據外週血內皮祖細胞(endothelial progenitor cells,EPCs)CD34~+水平評價高血壓病患者動脈血管病變程度.方法 高血壓病患者組62例,對照組20例.高血壓病患者採用Framingham心血管危險閡素積分分層心血管危險因素,分為低危組18例,中危組14例,高危組17例,極高危組13例.作外週血循環EPCs CD34~+水平、內皮依賴性血管舒張功能(flow-mediated dialation,FMD)測定併作EPCs CD34~+水平與Framingham心血管危險因素積分、FMD的相關性分析.結果 高血壓病患者外週循環EPCs CD34~+水平隨著其心血管危險程度的增加.逐步下降,各組間比較[1]差異均有顯著性(P<0.05).高血壓病患者肱動脈FMD隨著其心血管危險程度的增加顯著下降(P<0.01).各研究組高血壓病患者循環EPCs CD34~+水平與Framingham心血管危險因素積分呈負相關(r=-0.875,P<0.01),與肱動脈FMD呈正相關(r=0.859,P<0.01).結論 高血壓病患者循環EPCs CD34~+水平下降與心血管危險因素、動脈血管功能損傷有顯著的相關性.說明循環EPCs CD34~+水平可以作為評價高血壓病患者動脈血管病變的指標.
목적 탐토능부근거외주혈내피조세포(endothelial progenitor cells,EPCs)CD34~+수평평개고혈압병환자동맥혈관병변정도.방법 고혈압병환자조62례,대조조20례.고혈압병환자채용Framingham심혈관위험애소적분분층심혈관위험인소,분위저위조18례,중위조14례,고위조17례,겁고위조13례.작외주혈순배EPCs CD34~+수평、내피의뢰성혈관서장공능(flow-mediated dialation,FMD)측정병작EPCs CD34~+수평여Framingham심혈관위험인소적분、FMD적상관성분석.결과 고혈압병환자외주순배EPCs CD34~+수평수착기심혈관위험정도적증가.축보하강,각조간비교[1]차이균유현저성(P<0.05).고혈압병환자굉동맥FMD수착기심혈관위험정도적증가현저하강(P<0.01).각연구조고혈압병환자순배EPCs CD34~+수평여Framingham심혈관위험인소적분정부상관(r=-0.875,P<0.01),여굉동맥FMD정정상관(r=0.859,P<0.01).결론 고혈압병환자순배EPCs CD34~+수평하강여심혈관위험인소、동맥혈관공능손상유현저적상관성.설명순배EPCs CD34~+수평가이작위평개고혈압병환자동맥혈관병변적지표.
Objective To evaluate whether the variations in the number of circulating EPCs CD34~+ could be presented as the marker of artery vascular lesion in patients with hypertension. Methods 62 patients with hypertension and 20 healthy people were collected. Hypertension group were stratified by cardiovascular risk factors according to Framingham risk factors Score, and were divided into low-risk group of 18 cases, mid-risk group of 14 cases, high-risk group of 17 cases and much-high-risk group of 13 cases. The level of peripheral circulating EPCs CD34~+, brachial artery FMD were respectively measured. The relationships between the level of circulating EPCs CD34~+ and Framingham cardiovascular risk factors, brachial artery FMD were analyzed. Results The level of peripheral circulating EPCs CD34~+ was significantly lower in hypertension groups than that in control group (P<0.05). Brachial artery FMD was significantly lower in each hypertension groups than that was in control group (P<0.01). The scores of FMD and CD34~+ cells were inversely correlated with cardiovascular risks. There was a negative correlation between the level of circulating EPCs CD34~+ with Framingham cardiovascular risk factors(r =-0.875, P<0.01), a positive correlation with brachial artery FMD (r = 0.859, P<0.01). Conclusion The level of circulating EPCs is a predictor of artery vascular lesion in patients with hypertension.
