中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2010年
11期
974-979
,共6页
李又成%袁湘芝%黎金林%吴哲褒%李建策%李剑敏
李又成%袁湘芝%黎金林%吳哲褒%李建策%李劍敏
리우성%원상지%려금림%오철포%리건책%리검민
血管母细胞瘤%磁共振成像%诊断%Von Hippel-Lindau病
血管母細胞瘤%磁共振成像%診斷%Von Hippel-Lindau病
혈관모세포류%자공진성상%진단%Von Hippel-Lindau병
Hemangioblastoma%Magnetic resonance imaging%Diagnosis%Von Hippel-Lindau disease
目的 探讨散发性与Von Hippel-Lindau(VHL)病相关性颅内血管母细胞瘤的MRI表现类型及其病理基础.方法 2002年至2009年经手术病理证实的颅内血管母细胞瘤患者29例,将肿瘤MRI影像表现特点与手术病理结果做对照分析.结果 29例颅内血管母细胞瘤患者,散发性17例(59%),VHL病12例(41%),共计66个血管母细胞瘤,MRI表现为实性小结节型(28个)、实性肿块型(18个)及囊结节型(20个),病理光镜下表现为网状型、细胞型及混合型.结论 血管母细胞瘤的MRI表现类型与其病理基础密切相关.对VHL病患者颅内无症状的实性小结节型血管母细胞瘤应长期追踪观察.
目的 探討散髮性與Von Hippel-Lindau(VHL)病相關性顱內血管母細胞瘤的MRI錶現類型及其病理基礎.方法 2002年至2009年經手術病理證實的顱內血管母細胞瘤患者29例,將腫瘤MRI影像錶現特點與手術病理結果做對照分析.結果 29例顱內血管母細胞瘤患者,散髮性17例(59%),VHL病12例(41%),共計66箇血管母細胞瘤,MRI錶現為實性小結節型(28箇)、實性腫塊型(18箇)及囊結節型(20箇),病理光鏡下錶現為網狀型、細胞型及混閤型.結論 血管母細胞瘤的MRI錶現類型與其病理基礎密切相關.對VHL病患者顱內無癥狀的實性小結節型血管母細胞瘤應長期追蹤觀察.
목적 탐토산발성여Von Hippel-Lindau(VHL)병상관성로내혈관모세포류적MRI표현류형급기병리기출.방법 2002년지2009년경수술병리증실적로내혈관모세포류환자29례,장종류MRI영상표현특점여수술병리결과주대조분석.결과 29례로내혈관모세포류환자,산발성17례(59%),VHL병12례(41%),공계66개혈관모세포류,MRI표현위실성소결절형(28개)、실성종괴형(18개)급낭결절형(20개),병리광경하표현위망상형、세포형급혼합형.결론 혈관모세포류적MRI표현류형여기병리기출밀절상관.대VHL병환자로내무증상적실성소결절형혈관모세포류응장기추종관찰.
Objective To evaluate the MR imaging features of intracranial hemangioblastomas accompanying sporadic and yon Hippel - Lindau (VHL) disease with special attention to tumor types,correlation with surgical and pathologic findings,and any differences between patients with sporadic and VHL disease.Method The surgical pathology database of our institution was searched to identify all patients with histologically verified intracranial hemangioblastomas treated from 2002 to 2009.The medical,MR imaging,surgical,and pathological records of these patients were reviewed retrospectively and statistically analyzed.Serial MRI was obtained in von Hippel-Lindau disease patients.Results Twenty-nine patients (14 males and 15 females) presented with intracranial hemangioblastomas.Seventeen patients (59%)harbored sporadic hemangioblastomas.Twelve patients (41%) had VHL syndrome.These 29 patients presented with 66 hemangioblastomas(11 patients had multiple lesions).Patients with VHL disease tended to present with neurological symptoms and signs from younger age than patients with sporadic disease (P=0.000).The MRI findings of hemangioblastomas were classified as three types including small(10 mm or less) solid tumor,larger solid tumor,and cystic tumor with a mural nodule.Twenty-eight small solid hemangioblastomas occurred in 11 VHL disease patients,larger solid hemangioblastomas mostly in VHL disease patients,and cystic tumor with a mural nodule mostly in sporadic patients.Larger hemangioblastomas were mostly accompanied by vascular flow voids.Histologically,larger solid hemangioblastomas showed a large number of capillaries and a moderate number of stromal cells;the reverse was true in cystic-nodule tumors where capillaries were seen in moderate numbers and stromal cells were in abundance.Serial MRI in 7 VHL disease patients clearly showed 10 small solid hemangioblastomas that developed and evolved into 7 larger solid tumors and 3 cystic-nodule tumors.Conclusions The MRI features of intracranial hemangioblastomas were correlated with pathologic findings.In patients with VHL disease,MR imaging allows identification of lesions before they become symptomatic.Because patients with VHL disease are at risk of development of new lesions,they require life-long follow-up.