CAJ | 학술논문

目的:建立豚鼠至大鼠异种肝移植的动物模型。方法:利用血管套技术和显微外科技术进行了23例豚鼠至大鼠肝移植。观察存活时间、谷丙转氨酶（ALT）和移植肝病理变化、荧光染色。结果:移植大鼠存活时间平均为135.10±46.12分钟，肝细胞发生弥漫性水样变性，IgG和IgM沉积于血管内皮细胞和肝血窦。结论:豚鼠至大鼠异种移植模型存活时间有限，移植肝发生了超急性排斥反应。
목적:건립돈서지대서이충간이식적동물모형。방법:이용혈관투기술화현미외과기술진행료23례돈서지대서간이식。관찰존활시간、곡병전안매（ALT）화이식간병리변화、형광염색。결과:이식대서존활시간평균위135.10±46.12분종，간세포발생미만성수양변성，IgG화IgM침적우혈관내피세포화간혈두。결론:돈서지대서이충이식모형존활시간유한，이식간발생료초급성배척반응。
Objective：To establish the model of discordant xenotransplantaion in guinea pig-to-rat.Methods：We did 23 cases of xenotransplantation by the cuff and microsurgical techniques for vessel anastomoses. The survival time, ALT and histology were examined.Results：The mean survial time of receptor rats were(135.10±46.12) minutes. Diffusely swelling liver cells were found. There were both IgG and IgM deposition on the endothelium and hepatic sinus.Conclusion：Hyperacute rejection was found in our model.