CAJ | 학술논문

目的:利用弥散张量成像(diffusion tensor imaging, DTI)和静息状态下功能磁共振成像(functional magnetic resonance imaging, fMRI) 技术,探讨抑郁症可能的病因和发病机制.方法:对16例青年重性抑郁症患者(抑郁症组)和16例性别年龄及受教育程度匹配的自愿者(对照组)进行DTI和静息状态fMRI研究,采用基于体素法(voxel-based method, VBA)分析全脑的分数各向异性 (fractional anisotropy, FA),局部一致性(regional homogeneity, ReHo)法处理fMRI数据,并进行两组比较.结果:抑郁症患者双侧额中回、双侧中央前回、左颞上回、右颞中回、左梭状回、右枕颞外侧回、左角回、左岛叶、左小脑后叶的FA值较对照组低(P＜0.01).抑郁症患者双侧额上回、双侧额中回、双侧额叶内侧回、双侧中央旁小叶、双侧中央后回、右顶下小叶、右楔状叶、左枕中回、左语言中枢、左颞上回、右颞中回、右扣带回及右壳核ReHo值较对照组明显降低(P＜0.01).结论:青年重性抑郁症患者存在广泛的脑白质微观结构损害和脑功能异常,多个脑区及它们之间的结构和功能连接失常可能是抑郁症发病的重要因素之一.
목적:이용미산장량성상(diffusion tensor imaging, DTI)화정식상태하공능자공진성상(functional magnetic resonance imaging, fMRI) 기술,탐토억욱증가능적병인화발병궤제.방법:대16례청년중성억욱증환자(억욱증조)화16례성별년령급수교육정도필배적자원자(대조조)진행DTI화정식상태fMRI연구,채용기우체소법(voxel-based method, VBA)분석전뇌적분수각향이성 (fractional anisotropy, FA),국부일치성(regional homogeneity, ReHo)법처리fMRI수거,병진행량조비교.결과:억욱증환자쌍측액중회、쌍측중앙전회、좌섭상회、우섭중회、좌사상회、우침섭외측회、좌각회、좌도협、좌소뇌후협적FA치교대조조저(P＜0.01).억욱증환자쌍측액상회、쌍측액중회、쌍측액협내측회、쌍측중앙방소협、쌍측중앙후회、우정하소협、우설상협、좌침중회、좌어언중추、좌섭상회、우섭중회、우구대회급우각핵ReHo치교대조조명현강저(P＜0.01).결론:청년중성억욱증환자존재엄범적뇌백질미관결구손해화뇌공능이상,다개뇌구급타문지간적결구화공능련접실상가능시억욱증발병적중요인소지일.
Objective To explore the pathological mechanism of brain function and structure in young patients with major depressive disorder by diffusion tensor imaging(DTI)and resting state functional magnetic resonance imaging(fMRI).Methods Sixteen participants diagnosed with major depression (MD) and 16 healthy age and gender-matched controls(HC) were recruited. Resting state fMRI and DTI brain scans were performed on all participants. A voxel-based method (VBM) was used to analyze the DTI datasets, and regional homogeneity (ReHo) approach was applied to preprocess the fMRI datasets. The value of fractional anisotropy (FA) and ReHo maps were obtained in the whole brain.Results FA values in the MD group were significantly lower than those of the healthy controls in the white matter of the left middle temporal gyrus, right middle frontal gyrus, left medial frontal gyrus, right precentral gyrus, left angular gyrus, left fusiform gyrus, left superior temporal gyrus, right middle temporal gyrus, right sub-gyral, left insula, and left pyramis (P＜0.01). ReHo in the MD group decreased in the left superior frontal gyrus, right superior frontal gyrus, left middle frontal gyrus, right middle frontal gyrus, left medial frontal gyrus, right medial frontal gyrus, left paracentral lobule, right paracentral lobule, right inferior parietal lobule, left postcentral gyrus, right postcentral gyrus, left middle occipital gyrus, left lingual gyrus, right putamen, right cingulate gyrus, right cuneus, left superior temporal gyrus, and right middle temporal gyrus (P＜0.01). Conclusion Abnormality of brain white microstructure and function exist widely in young patients with major depressive disorder. Abnormal connection of structures and function between the brain areas may be the key reason for the depression.