CAJ | 학술논문

随着PET、PET-CT技术的迅速发展,18F标记的放射性氨基酸药物在临床上的应用越来越广泛.由于18F具有优越的物理特性、相对长的半衰期(110min)、其类氢特性不致于引起标记分子的空间结构发生明显改变,因此18F是用于PET的放射性核素的最佳选择.而天然氨基酸存在易代谢及代谢复杂的特点,所以近来人们对非天然氨基酸的研究逐渐增多,如酪氨酸衍生物、苯丙氨酸衍生物、脯氨酸衍生物、甲硫氨酸衍生物等.综述了近年来18F标记的非天然氨基酸及其衍生物的研究进展.
수착PET、PET-CT기술적신속발전,18F표기적방사성안기산약물재림상상적응용월래월엄범.유우18F구유우월적물리특성、상대장적반쇠기(110min)、기류경특성불치우인기표기분자적공간결구발생명현개변,인차18F시용우PET적방사성핵소적최가선택.이천연안기산존재역대사급대사복잡적특점,소이근래인문대비천연안기산적연구축점증다,여락안산연생물、분병안산연생물、포안산연생물、갑류안산연생물등.종술료근년래18F표기적비천연안기산급기연생물적연구진전.
Along with the rapid development of PET and PET-CT technologies,the application of 18F-labelled radiopharmaceuticals is more and more widespread in clinic.18F has predominant physical features with long half-life(110min).Also,the chemical nature of 18F is similar to that of hydrogen,it can't change the labelled molecular's character obviously.Therefore,the 18F is the best choice of radionuclide used in PET.However,natural animo acid has the character of metabolizing easily and complexly,the studies in non-natrual animo acid have increased gradually such as tyrosine derivatives,phenylalanine derivatives,proline derivatives,methionine derivatives,and so on.The article summarizes the 18F-labelled non-natural amino acids and their derivatives studied in recent years.