CAJ | 학술논문

目的探讨儿童特发性血小板减少性紫癜(ITP)联合抗病毒治疗前后Pt、血小板平均容积(MPV)、血小板压积(PCT)、血小板分布宽度(PDw)等参数变化.方法采用日本生产的XT-1800i血细胞分析仪测定110例ITP患儿(病例组)联合抗病毒治疗前后Pt、MPV、PCT、PDW,其中轻度组16例、中度组38例、重度组30例、极重度组26例.并与110例健康体检儿童(对照组)进行比较.结果 ITP患儿轻度组与中度组、中度组与重度组、重度组与极重度组比较MPV、PDW、PCT差异均有统计学意义(P均<0.01),极重度组与轻度组比较PCT差异有统计学意义(P<0.01);病例组治疗前与治疗后及对照组Pt、PCT及MPV、PDW比较差异有统计学意义(P<0.01),病例组治疗后与对照组比较Pt、PCT仍低(P<0.05).结论动态监测血小板参数可反映ITP病情变化,指导临床治疗.
목적 탐토인동특발성혈소판감소성자전(ITP)연합항병독치료전후Pt、혈소판평균용적(MPV)、혈소판압적(PCT)、혈소판분포관도(PDw)등삼수변화.방법 채용일본생산적XT-1800i혈세포분석의측정110례ITP환인(병례조)연합항병독치료전후Pt、MPV、PCT、PDW,기중경도조16례、중도조38례、중도조30례、겁중도조26례.병여110례건강체검인동(대조조)진행비교.결과 ITP환인경도조여중도조、중도조여중도조、중도조여겁중도조비교MPV、PDW、PCT차이균유통계학의의(P균<0.01),겁중도조여경도조비교PCT차이유통계학의의(P<0.01);병례조치료전여치료후급대조조Pt、PCT급MPV、PDW비교차이유통계학의의(P<0.01),병례조치료후여대조조비교Pt、PCT잉저(P<0.05).결론 동태감측혈소판삼수가반영ITP병정변화,지도림상치료.
Objective To study the changes of parameters of platelet (Pt), mean platelet volume( MPV ), platelet constrict volume ( PCT ), and platelet distribution width (PDW) in child idiopathic thrombocytopenic purpura (ITP) before and after anti-virus treatment. Methods Pt,MPV,PCT and PDW were determined in 110 cases with child ITP, including slight group ( 16 cases), medium group(38 cases ), serious group (30 cases) and more serious group (26 cases) before and after treatment with anti-virus as well as in 110 normal controls with XT-1800i auto blood cell analysis instrument. Results There were significant differences on MPV, PDW and PCT between the patients of slight group and medium group, and so on medium group and serious group, serious group and more serious group (P<0.01 ).There was significant difference on PCT between the patients of slight group and more serious group (P<0.01 ). Before treatment, in the patients the MPV, PDW were significantly higher and the Pt, PCT were significantly lower than those in the controls and after treatment (P<0.01 ). After treatment,the levels of Pt and PCT were lower in the patients than those in the controls (P<0.05), but , MPV, PDW were no difference. Conclusion Dynamic changes of parameter of platelet could reflect the progress of ITP and could guide clinical treatment.