CAJ | 학술논문

目的观察肺保护性通气联合热毒宁注射液治疗急性肺损伤的临床疗效.方法 59例急性肺损伤(ALI)患者随机对照分为肺保护性通气组(对照组,n=30)和肺保护性通气联合热毒宁注射液治疗组(治疗组n=29),观察两组的临床生命体征、呼吸(RR)、血气分析等改变,进行PaO2和PaO2/FiO2比较、疗效评价及住院期间病死率统计分析.结果治疗组患者肺损伤得到控制者21例(72.41%),与对照组的14例(46.67%)比较差异有统计学意义(P<0.05);治疗组PaO2上升,PaO2/FiO2显著上升(P<0.01).病死率治疗组为24.14%明显低于对照组的50.00%(P<0.05).结论热毒宁注射液对急性肺损伤肺保护性通气具有改善肺功能作用,并可降低住院病死率.
목적 관찰폐보호성통기연합열독저주사액치료급성폐손상적림상료효.방법 59례급성폐손상(ALI)환자수궤대조분위폐보호성통기조(대조조,n=30)화폐보호성통기연합열독저주사액치료조(치료조n=29),관찰량조적림상생명체정、호흡(RR)、혈기분석등개변,진행PaO2화PaO2/FiO2비교、료효평개급주원기간병사솔통계분석.결과 치료조환자폐손상득도공제자21례(72.41%),여대조조적14례(46.67%)비교차이유통계학의의(P<0.05);치료조PaO2상승,PaO2/FiO2현저상승(P<0.01).병사솔치료조위24.14%명현저우대조조적50.00%(P<0.05).결론 열독저주사액대급성폐손상폐보호성통기구유개선폐공능작용,병가강저주원병사솔.
Objective To evaluate the clinical effect of the lung protective ventilation combining with Re-duning injection on the acute lung injury (ALI). Methods 59 patients with ALI were randomly divided into the lung protective ventilation group (control group, n =30) and the lung protective ventilation wmbined with Reduning injection group(experimental group,n = 29) ,and the changes of vital signs,RR,blood gas analysis,and so on were observed. The comparison between PaO2 and PaO2/FiO2 was carried out. The efficacy and the mortality rate were evaluated. Results Lung injury in 21 cases of experimental group were improved after applied Reduning treatment(72. 41%),there was a significant difference ( P < 0.05) with that of 14 cases in control group (46. 67% ) ; PaO2 increased, PaO2/FiO2 significantly increased in experiment group,there were significant difference compared with those of control group(P <0. 01). The mortality rate in the experimental group was 24.14% ,there was a significant differ-ence(P<0.05) compared with the mortality of 50. 00% in control group. Conclusion Reduning treatment could, improve the pulmonary function in lung protective ventilation to cure ALI,reducing the mortality rate as well.