CAJ | 학술논문

目的分析和比较中国与欧洲地区动脉瘤性蛛网膜下腔出血（aneury smal subarachnoid hemorrhage，aSAH）患者脑血管痉挛(cerebral vasospasm,CVS)发生率。方法利用MEDLINE和CNKI数据库对所有探讨aSAH后CVS发生率、诊断、治疗或预后的临床研究进行检索（检索时间1990年1月1日-2010年12月31日），记录血管造影性CVS、有症状CVS和CVS相关性梗死发生率，对中国和欧洲白人aSAH患者CVS发生率进行比较。结果通过CNKI数据库和参考文献回顾共检索到237篇文献，其中9项研究符合纳入标准；通过MEDLINE数据库和参考文献回顾共检索到172篇文献，其中18项研究符合纳入标准。中国aSAH患者发生有症状CVS的风险显著高于欧洲白人患者（相对危险度为2.063，95％可信区间1.816～2.343;P＜0.001）。结论中国aSAH患者有症状CVS发生率显著高于欧洲白人患者，提示CVS的发生机制可能存在遗传学基础。
목적분석화비교중국여구주지구동맥류성주망막하강출혈（aneury smal subarachnoid hemorrhage，aSAH）환자뇌혈관경련(cerebral vasospasm,CVS)발생솔。방법이용MEDLINE화CNKI수거고대소유탐토aSAH후CVS발생솔、진단、치료혹예후적림상연구진행검색（검색시간1990년1월1일-2010년12월31일），기록혈관조영성CVS、유증상CVS화CVS상관성경사발생솔，대중국화구주백인aSAH환자CVS발생솔진행비교。결과통과CNKI수거고화삼고문헌회고공검색도237편문헌，기중9항연구부합납입표준；통과MEDLINE수거고화삼고문헌회고공검색도172편문헌，기중18항연구부합납입표준。중국aSAH환자발생유증상CVS적풍험현저고우구주백인환자（상대위험도위2.063，95％가신구간1.816～2.343;P＜0.001）。결론중국aSAH환자유증상CVS발생솔현저고우구주백인환자，제시CVS적발생궤제가능존재유전학기출。
Objective To analyze and compare the incidence of cerebral vasospasm (CVS) in patients with aneurismal subarachnoid hemorrhage(aSAH) in China and in Europe.Methods A literature search was performed for all the papers investigating the incidence,diagnosis, treatment or prognosis of CVS after aSAH using the MEDLINE and China Knowledge Resource Integrated Database (CNKI) from January 1, 1990 to December 31, 2010.The incidences of angiographic CVS, symptomatic CVS and CVS-related infarcts were recorded.The incidences of CVS between Chinese and white men in Europe were compared. Results A total of 237 articles were searched via CNKI and reference reviews, and 9 of the studies met the inclusion criteria. A total of 172 articles were searched via MEDLINE and reference reviews, and 18 of the studies met the inclusion criteria. The risk of occurring symptomatic CVS in patients with aSAH in Chinese was significantly higher than that in white men in Europe (relative risk,2. 063, 95％ confidence interval 1.816-2. 343, P ＜0. 001). Conclusions The incidence of CVS in patients with aSAH in Chinese was significantly higher than that in white men in Europe,indicating the pathogenesis of CVS may have genetic basis.