目的 分析全身DWI(WB-DWI)上的骨髓正常表现及其影响因素.方法 对98名健康志愿者(男47名,女51名)进行WB-DWI扫描,测量胸椎、腰椎、双侧股骨(头、颈、上段、远端)、髂骨、肱骨头、肩胛骨的ADC值、DWI(b=800 s/mm2)及STIR信号值.采用秩相关性检验分析骨髓DWI信号值与ADC值及STIR信号值的关系,不同部位骨髓ADC值比较采用ANOVA法,两两比较采用Student-Newman- Keuls检验,男女不同部位骨髓ADC值与年龄的相关性分析采用秩相关检验.结果 (1)98名志愿者中,69名骨髓呈低至中等信号,其中女24名、男45名；29名骨髓呈高信号,其中女27名、男2名.(2)胸椎、腰椎、股骨头、股骨颈、股骨上段、髂骨、肱骨头、肩胛骨骨髓DWI信号值(M值分别为44.54、35.01、13.61、16.00、21.45、25.77、18.35、36.12)与ADC值[(0.55±0.08)×10-3、(0.53±0.08) ×10- 3、(0.30 ±0.10)×10- 3、(0.42 ±0.16)×10-3、(0.74±0.14)×10-3、(0.49±0.10)×10-3、(0.36±0.13)× 10-3、(0.49±0.11)×10 -3mm2/s]及STIR信号值(M值分别为61.81、64.99、53.27、69.08、73.10、66.35、73.16、79.81)呈正相关,r值分别为0.513、0.695,0.741、0.764,0.443、0.489,0.641、0.656,0.510、0.648,0.475、0.715,0.366、0.446,0.437、0.739,P值均＜0.01.(3)不同部位骨髓ADC值差异有统计学意义(F=138.69,P＜0.01).胸椎与腰椎、髂骨与肩胛骨,股骨头与股骨远端之间差异无统计学意义(P值均＞0.05),其余任意两组差异均有统计学意义(P值均＜ 0.05).(4)女性胸椎[(0.59±0.07) ×10-3 mm2/s]、腰椎[(0.58 ±0.06)×10-3 mm2/s]、股骨头(M值0.33×10-3 mm2/s)、股骨颈(M值0.53×10-3 mm2/s)、股骨上段(M值0.81×10-3mm2/s)、股骨远端(M值0.32×10-3 mm2/s)、髂骨[(0.52 ±0.09)×10-3 mm2/s]、肱骨头(M值0.42×10-3mm2/s)、肩胛骨[(0.53±0.09)×10-3 mm2/s]骨髓ADC值均高于男性[(0.51 ±0.07)×10-3、(0.48±0.07)×10-3、M值0.23×10-3、M值0.31×10-3、M值0.66×10-3、M值0.23×10-3、(0.46±0.10)×10-3、M值0.27×10-3、(0.45 ±0.11)×10-3mm2/s].(5)女性胸椎、腰椎、股骨(头、颈、上段)、髂骨、肱骨头骨髓ADC值与年龄呈负相关(r值分别为- 0.549、- 0.629、- 0.329、-0.524、-0.338、-0.548和-0.416,P值均＜0.05),而女性股骨远端、肩胛骨和男性各部位骨髓ADC值与年龄无明显相关性(P值均＞0.05).结论 骨髓ADC值及STIR信号值越高,其DWI(b=800 s/mm2)信号值越高；骨髓ADC值受年龄和性别影响,不同部位骨髓ADC值不同.
目的 分析全身DWI(WB-DWI)上的骨髓正常錶現及其影響因素.方法 對98名健康誌願者(男47名,女51名)進行WB-DWI掃描,測量胸椎、腰椎、雙側股骨(頭、頸、上段、遠耑)、髂骨、肱骨頭、肩胛骨的ADC值、DWI(b=800 s/mm2)及STIR信號值.採用秩相關性檢驗分析骨髓DWI信號值與ADC值及STIR信號值的關繫,不同部位骨髓ADC值比較採用ANOVA法,兩兩比較採用Student-Newman- Keuls檢驗,男女不同部位骨髓ADC值與年齡的相關性分析採用秩相關檢驗.結果 (1)98名誌願者中,69名骨髓呈低至中等信號,其中女24名、男45名；29名骨髓呈高信號,其中女27名、男2名.(2)胸椎、腰椎、股骨頭、股骨頸、股骨上段、髂骨、肱骨頭、肩胛骨骨髓DWI信號值(M值分彆為44.54、35.01、13.61、16.00、21.45、25.77、18.35、36.12)與ADC值[(0.55±0.08)×10-3、(0.53±0.08) ×10- 3、(0.30 ±0.10)×10- 3、(0.42 ±0.16)×10-3、(0.74±0.14)×10-3、(0.49±0.10)×10-3、(0.36±0.13)× 10-3、(0.49±0.11)×10 -3mm2/s]及STIR信號值(M值分彆為61.81、64.99、53.27、69.08、73.10、66.35、73.16、79.81)呈正相關,r值分彆為0.513、0.695,0.741、0.764,0.443、0.489,0.641、0.656,0.510、0.648,0.475、0.715,0.366、0.446,0.437、0.739,P值均＜0.01.(3)不同部位骨髓ADC值差異有統計學意義(F=138.69,P＜0.01).胸椎與腰椎、髂骨與肩胛骨,股骨頭與股骨遠耑之間差異無統計學意義(P值均＞0.05),其餘任意兩組差異均有統計學意義(P值均＜ 0.05).(4)女性胸椎[(0.59±0.07) ×10-3 mm2/s]、腰椎[(0.58 ±0.06)×10-3 mm2/s]、股骨頭(M值0.33×10-3 mm2/s)、股骨頸(M值0.53×10-3 mm2/s)、股骨上段(M值0.81×10-3mm2/s)、股骨遠耑(M值0.32×10-3 mm2/s)、髂骨[(0.52 ±0.09)×10-3 mm2/s]、肱骨頭(M值0.42×10-3mm2/s)、肩胛骨[(0.53±0.09)×10-3 mm2/s]骨髓ADC值均高于男性[(0.51 ±0.07)×10-3、(0.48±0.07)×10-3、M值0.23×10-3、M值0.31×10-3、M值0.66×10-3、M值0.23×10-3、(0.46±0.10)×10-3、M值0.27×10-3、(0.45 ±0.11)×10-3mm2/s].(5)女性胸椎、腰椎、股骨(頭、頸、上段)、髂骨、肱骨頭骨髓ADC值與年齡呈負相關(r值分彆為- 0.549、- 0.629、- 0.329、-0.524、-0.338、-0.548和-0.416,P值均＜0.05),而女性股骨遠耑、肩胛骨和男性各部位骨髓ADC值與年齡無明顯相關性(P值均＞0.05).結論 骨髓ADC值及STIR信號值越高,其DWI(b=800 s/mm2)信號值越高；骨髓ADC值受年齡和性彆影響,不同部位骨髓ADC值不同.
목적 분석전신DWI(WB-DWI)상적골수정상표현급기영향인소.방법 대98명건강지원자(남47명,녀51명)진행WB-DWI소묘,측량흉추、요추、쌍측고골(두、경、상단、원단)、가골、굉골두、견갑골적ADC치、DWI(b=800 s/mm2)급STIR신호치.채용질상관성검험분석골수DWI신호치여ADC치급STIR신호치적관계,불동부위골수ADC치비교채용ANOVA법,량량비교채용Student-Newman- Keuls검험,남녀불동부위골수ADC치여년령적상관성분석채용질상관검험.결과 (1)98명지원자중,69명골수정저지중등신호,기중녀24명、남45명；29명골수정고신호,기중녀27명、남2명.(2)흉추、요추、고골두、고골경、고골상단、가골、굉골두、견갑골골수DWI신호치(M치분별위44.54、35.01、13.61、16.00、21.45、25.77、18.35、36.12)여ADC치[(0.55±0.08)×10-3、(0.53±0.08) ×10- 3、(0.30 ±0.10)×10- 3、(0.42 ±0.16)×10-3、(0.74±0.14)×10-3、(0.49±0.10)×10-3、(0.36±0.13)× 10-3、(0.49±0.11)×10 -3mm2/s]급STIR신호치(M치분별위61.81、64.99、53.27、69.08、73.10、66.35、73.16、79.81)정정상관,r치분별위0.513、0.695,0.741、0.764,0.443、0.489,0.641、0.656,0.510、0.648,0.475、0.715,0.366、0.446,0.437、0.739,P치균＜0.01.(3)불동부위골수ADC치차이유통계학의의(F=138.69,P＜0.01).흉추여요추、가골여견갑골,고골두여고골원단지간차이무통계학의의(P치균＞0.05),기여임의량조차이균유통계학의의(P치균＜ 0.05).(4)녀성흉추[(0.59±0.07) ×10-3 mm2/s]、요추[(0.58 ±0.06)×10-3 mm2/s]、고골두(M치0.33×10-3 mm2/s)、고골경(M치0.53×10-3 mm2/s)、고골상단(M치0.81×10-3mm2/s)、고골원단(M치0.32×10-3 mm2/s)、가골[(0.52 ±0.09)×10-3 mm2/s]、굉골두(M치0.42×10-3mm2/s)、견갑골[(0.53±0.09)×10-3 mm2/s]골수ADC치균고우남성[(0.51 ±0.07)×10-3、(0.48±0.07)×10-3、M치0.23×10-3、M치0.31×10-3、M치0.66×10-3、M치0.23×10-3、(0.46±0.10)×10-3、M치0.27×10-3、(0.45 ±0.11)×10-3mm2/s].(5)녀성흉추、요추、고골(두、경、상단)、가골、굉골두골수ADC치여년령정부상관(r치분별위- 0.549、- 0.629、- 0.329、-0.524、-0.338、-0.548화-0.416,P치균＜0.05),이녀성고골원단、견갑골화남성각부위골수ADC치여년령무명현상관성(P치균＞0.05).결론 골수ADC치급STIR신호치월고,기DWI(b=800 s/mm2)신호치월고；골수ADC치수년령화성별영향,불동부위골수ADC치불동.
Objective To analyze the pattern of normal bone marrow on whole body diffusionweighted imaging (WB-DWI) and its influence factors.Methods A total of 98 healthy volunteers (male 47 and female 51). All volunteers underwent WB-DWI at 1.5 T MR scan. The ADC value,the signal intensity on DWI obtained with a b value of 800 s/mm2 ( SIDWI ),and the signal intensity on short time inversion recovery images ( SISTIR ) of thoracic vertebrae,lumber vertebrae,bilateral head of femur,bilateral neck of femur,bilateral superior segment of femur,bilateral inferior segment of femur,bilateral ilium,bilateral head of humerus,bilateral scapula were measured and compared with ANOVA test and StudentNewmar-Keuls test.The normal appearance of bone marrow on WB-DW[ was assessed. The relationship between the SIDwI and the ADC,and the SIDWI and the SISTIR of bone marrow were analyzed.The ADC of bone marrow between male and femaIe were compared. Spearman correlation analysis was performed for different age groups.Results ( 1 ) Bone marrow signal intensity was different among 98 healthy volunteers.Bone marrow in 69 healthy volunteers (female 24,male 45 ) showed low to intermediate signal intensity,whereas in the remaining 29 healthy volunteers (female 27,male 2) showed high signal intensity.(2) The SIDWI of thoracic vertebrae ( median 44.54),lumber vertebrae ( median 35.01 ),head of femur ( median 13.61 ),neck of femur ( median 16.00),superior segment of femur ( median 21.45 ),ilium ( median 25.77),head of humerus (median 18.35),scapula (median 36.12) was positively correlated with the ADC [ (0.55 ±0.08) × l0-3,(0.53 ±0.08) × 10-3,(0.30 ± 0.10) × 10-3,(0.42 ± 0.16) × 10-3,(0.74±0.14) ×l0- 3,(0.49±0.10) ×10-3,(0.36±0.13) ×10-3,(0.49±0.11) × 10-3mm2/s]and the SISTIR ( median 61.81,64.99,53.27,69.08,73.10,66.35,73.16,79.81 ),r =0.513 and 0.695,0.741 and 0.764,0.443 and 0.489,0.641 and 0.656,0.510 and 0.648,0.475 and 0.715,0.366 and 0.446,0.437 and 0.739 ;P ＜ 0.01. (3) There was significant difference of the ADC of bone marrow in different bone,F =138.69,P ＜ 0.01. Student-Newman-Keuls test revealed that no significant difference was found in the ADC between thoracic vertebrae and lumbar vertebrae,ilium and scapula,head of humerus and inferior segment of femur ( P ＞ 0.05 ),and significant difference was found in the ADC values between the remaining two groups ( P ＜ 0.05 ). The bones associated with decreasing ADC values were superior segment of femur,thoracic vertebrae and lumber vertebrae,ilium and scapula,neck of femur,head of humerus,head of femur and inferior segment of femur. ( 4 ) The ADC values of bone marrow of female subjects in thoracic vertebrae [ (0.59 ±0.07) × 10-3 mm2/s],lumber vertebrae [ (0.58 ±0.06) × 10 -3 mm2/s],head of femur ( median 0.33 × 10 -3 mm2/s),neck of femur ( median 0.53 × 10 -3 mm2/s),superior segment of femur ( median 0.81 × 10-3 mm2/s),inferior segment of femur ( median 0.32 ×10-3 mm2/s),ilium [ (0.52 ± 0.09 ) × 10-3 mm2/s ],head of humerus (median 0.42 × 10-3 mm2/s),scapula [ (0.53 ± 0.09) × 10-3 mm2/s] were significantly higher than those of male subjects [ (0.51 ±0.07) × 10-3,(0.48 ±0.07) × 10-3,median 0.23 × 10-3,median 0.31 × 10-3,median 0.66 × 10-3,median 0.23 × 10-3,(0.46 ±0.10) × 10-3,median 0.27 × 10-3,(0.45 ±0.11 ) × 10 3mm2/s].(5)There was significant negative correlation between the ADC values of bone marrow and age in thoracic vertebrae,lumber vertebrae,head of femur,neck of femur,superior segment of femur,ilium,head of humerus for female subjects,r =-0.549, -0.629, -0.329, -0.524, -0.338, -0.548 and -0.416,respectively,P ＜ 0.05.There was no significant correlation between ADC values and age in inferior segment of femur and scapula for female subjects and all the regions for male subjects ( P ＞ 0.05 ).Conclusions The ADC and the SIsTIR of bone marrow correlates with the SIDW1.The ADC values of bone marrow is affected by age and sex,and is different for different bones.
