肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
6期
390-392,395
,共4页
喉肿瘤%PTEN磷酸水解酶%抗原,CD44v6%细胞分化%肿瘤转移
喉腫瘤%PTEN燐痠水解酶%抗原,CD44v6%細胞分化%腫瘤轉移
후종류%PTEN린산수해매%항원,CD44v6%세포분화%종류전이
Laryngeal neoplasms%PTEN phosphohydrolase%Antigens,CD44v6%Cell differentiation%Neoplasms metastasis
目的 探讨PTEN蛋白和CD44v6检测在提示喉鳞状细胞癌(以下简称喉癌)分化和颈部淋巴结转移中的作用.方法 运用免疫组织化学SP法,检测97例喉癌组织标本和距离病变范围2.5 cm以上的癌旁组织中PTEN蛋白和CD44v6的表达情况.进行合理的统计学设计,分析各项指标之间的相互关系及其与喉癌某些临床指标之间的关系.结果 PTEN蛋白在喉癌组中表达率为55.67%(54/97),癌旁组中为100%(97/97),二者差异有统计学意义(P<0.01).PTEN蛋白的表达在高、中、低分化不同组织类型中的差异具有统计学意义(P<0.05),但在颈部淋巴结转移阳性组和阴性组中表达差异无统计学意义(P>0.05).CD44v6在颈部淋巴结转移阳性组的表达明显高于阴性组,差异有统计学意义(P<0.05),且在高、中、低分化不同组织类型中的表达差异也有统计学意义(P<0.05).PTEN蛋白低表达与CD44v6高表达呈负相关性(r=0.652,P<0.05).结论 PTEN蛋白对预测喉癌颈部淋巴结转移无意义,但对提示其分化程度具有一定意义.CD44v6在预测颈部淋巴结转移及提示喉癌分化程度中均具有统计学意义.
目的 探討PTEN蛋白和CD44v6檢測在提示喉鱗狀細胞癌(以下簡稱喉癌)分化和頸部淋巴結轉移中的作用.方法 運用免疫組織化學SP法,檢測97例喉癌組織標本和距離病變範圍2.5 cm以上的癌徬組織中PTEN蛋白和CD44v6的錶達情況.進行閤理的統計學設計,分析各項指標之間的相互關繫及其與喉癌某些臨床指標之間的關繫.結果 PTEN蛋白在喉癌組中錶達率為55.67%(54/97),癌徬組中為100%(97/97),二者差異有統計學意義(P<0.01).PTEN蛋白的錶達在高、中、低分化不同組織類型中的差異具有統計學意義(P<0.05),但在頸部淋巴結轉移暘性組和陰性組中錶達差異無統計學意義(P>0.05).CD44v6在頸部淋巴結轉移暘性組的錶達明顯高于陰性組,差異有統計學意義(P<0.05),且在高、中、低分化不同組織類型中的錶達差異也有統計學意義(P<0.05).PTEN蛋白低錶達與CD44v6高錶達呈負相關性(r=0.652,P<0.05).結論 PTEN蛋白對預測喉癌頸部淋巴結轉移無意義,但對提示其分化程度具有一定意義.CD44v6在預測頸部淋巴結轉移及提示喉癌分化程度中均具有統計學意義.
목적 탐토PTEN단백화CD44v6검측재제시후린상세포암(이하간칭후암)분화화경부림파결전이중적작용.방법 운용면역조직화학SP법,검측97례후암조직표본화거리병변범위2.5 cm이상적암방조직중PTEN단백화CD44v6적표체정황.진행합리적통계학설계,분석각항지표지간적상호관계급기여후암모사림상지표지간적관계.결과 PTEN단백재후암조중표체솔위55.67%(54/97),암방조중위100%(97/97),이자차이유통계학의의(P<0.01).PTEN단백적표체재고、중、저분화불동조직류형중적차이구유통계학의의(P<0.05),단재경부림파결전이양성조화음성조중표체차이무통계학의의(P>0.05).CD44v6재경부림파결전이양성조적표체명현고우음성조,차이유통계학의의(P<0.05),차재고、중、저분화불동조직류형중적표체차이야유통계학의의(P<0.05).PTEN단백저표체여CD44v6고표체정부상관성(r=0.652,P<0.05).결론 PTEN단백대예측후암경부림파결전이무의의,단대제시기분화정도구유일정의의.CD44v6재예측경부림파결전이급제시후암분화정도중균구유통계학의의.
Objective To investigate the importance of PTEN protein and CD44v6 detection to the prediction of laryngeal carcinoma differentiation and cervical lymph node metastasis. Methods The expressions of PTEN protein and CD44v6 were detected by immunohistochemical SP method in 97 specimens with laryngeal carcinoma and 97 specimens with a distance over 2.5 centimeters from laryngeal carcinoma. The relations between them and their clinical significance to the laryngeal squamous cell carcinoma above Glottis by the statistical analyses tools were revealed. Results The positive expression rates of PTEN protein were respectively 55.67 %, 100 % in laryngeal carcinoma and adjacent carcinoma tissue. There was a significant difference between them statistically (P<0.01). The positive expression rates of PTEN protein are notable difference among the high, middle and low differentiation of laryngeal carcinoma, but not between the positive metastasis of lymph node of neck and the negative one(P >0.05). For the expression of CD44v6, there were notable statistical difference not only among the different differentiation of laryngeal careinoma, but also between the positive metastasis of lymph node of neck and the negative one. The low expressions of PTEN protein and the high expression of CD44v6 in the same carcinoma cell has significant negative correlation (P< 0.05). Conclusion PTEN protein may have the importance to the differentiation of laryngeal carcinoma, but no means to cervical lymph node metastasis. CD44v6 may have great importance to both.
