CAJ | 학술논문

目的探讨HepaSphere微球血管内栓塞治疗高流量动静脉畸形(artefiovenous inalforma-tions,AVM)的疗效.方法 HepaSphere微球吸水后膨胀变软、直径大小可控制.13例AVM患者采用HepaSphere微球血管内栓塞治疗,其中3例栓塞后联合手术治疗.随访3个月至3年,根据临床症状的改善情况和影像学检查资料评价疗效.结果 13例共进行28次栓塞治疗,10例单纯栓塞、3例(2例颌面部、1例肺部AVM)栓塞后手术完全切除,弥漫性AVM多次栓塞后症状均有所改善.组织学显示HepaSphere微球充填血管导致血管腔阻塞,血管壁炎性反应轻微.结论 HepaSphere微球血管内栓塞治疗高流量AVM安全有效,对弥漫性AVM需要联合多种方法治疗.
목적 탐토HepaSphere미구혈관내전새치료고류량동정맥기형(artefiovenous inalforma-tions,AVM)적료효.방법 HepaSphere미구흡수후팽창변연、직경대소가공제.13례AVM환자채용HepaSphere미구혈관내전새치료,기중3례전새후연합수술치료.수방3개월지3년,근거림상증상적개선정황화영상학검사자료평개료효.결과 13례공진행28차전새치료,10례단순전새、3례(2례합면부、1례폐부AVM)전새후수술완전절제,미만성AVM다차전새후증상균유소개선.조직학현시HepaSphere미구충전혈관도치혈관강조새,혈관벽염성반응경미.결론 HepaSphere미구혈관내전새치료고류량AVM안전유효,대미만성AVM수요연합다충방법치료.
Objective To determine the effect, safety, and feasibility of embolization of high flow arteriovenous malformations(AVMs) with HepaSphere mierospheres. Methods HepeSphere particles swell by absorbing fluids and become soft and deformable with a precisely calibrated diameter. 13 patients with AVMs were treated by transarterial embolization with HepaSphere particles. 3 cases underwent a following AVMs resection surgery. The follow-up period was 3 months to 3 years. Symptoms improvement and image examination were studied. Results 28 transarterial embolizations were performed in 13 cases. The resection operation was performed in 3 cases after transarterial embolizations. The symptoms in diffused AVMs improved after several transarterial embolizations. Histologically, HepaSphere particles penetrated into the intralesional vessels and conformed to the vessel lumen, resulting in vessel occlusion. Minimal perivascular reaction was observed. Conclusions Embolization of high flow AVMs with HepeSphere microspheres is safe and effective. Combined treatment is necessary for diffuse AVMs.