中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
24期
34-35
,共2页
胰腺癌%PTEN%Survivin
胰腺癌%PTEN%Survivin
이선암%PTEN%Survivin
Pancreatic cancer%PTEN%Survivin
目的 探讨胰腺癌及正常胰腺组织中PTEN和Survivin的表达及PTEN和Survivin在胰腺癌发展中的作用.方法 采用免疫组化的方法检测48例胰腺癌中及15例正常胰腺组织中PETN、Survivin的表达情况.结果 48例胰腺癌组织标本中PTEN、Survivin表达阳性率分别为31.3％ (15/48)、77.1％ (37/48),正常胰腺组织标本中PTEN、Survivin表达阳性率分别为66.7％(10/15)、0(0/15),两者比较差异有统计学意义(P＜0.05)；胰腺癌组织中PETN、Survivin的表达与患者的性别、年龄均无关(P＞0.05),与癌细胞分化程度、淋巴结转移及TNM分期有关(P＜0.05).Survivin与PETN在胰腺癌组织中的表达呈负相关(r=- 0.381,P＜0.05).结论 Survivin 的异常高水平表达及PTEN的表达缺失与胰腺癌的发生、发展、转移及浸润密切相关.
目的 探討胰腺癌及正常胰腺組織中PTEN和Survivin的錶達及PTEN和Survivin在胰腺癌髮展中的作用.方法 採用免疫組化的方法檢測48例胰腺癌中及15例正常胰腺組織中PETN、Survivin的錶達情況.結果 48例胰腺癌組織標本中PTEN、Survivin錶達暘性率分彆為31.3％ (15/48)、77.1％ (37/48),正常胰腺組織標本中PTEN、Survivin錶達暘性率分彆為66.7％(10/15)、0(0/15),兩者比較差異有統計學意義(P＜0.05)；胰腺癌組織中PETN、Survivin的錶達與患者的性彆、年齡均無關(P＞0.05),與癌細胞分化程度、淋巴結轉移及TNM分期有關(P＜0.05).Survivin與PETN在胰腺癌組織中的錶達呈負相關(r=- 0.381,P＜0.05).結論 Survivin 的異常高水平錶達及PTEN的錶達缺失與胰腺癌的髮生、髮展、轉移及浸潤密切相關.
목적 탐토이선암급정상이선조직중PTEN화Survivin적표체급PTEN화Survivin재이선암발전중적작용.방법 채용면역조화적방법검측48례이선암중급15례정상이선조직중PETN、Survivin적표체정황.결과 48례이선암조직표본중PTEN、Survivin표체양성솔분별위31.3％ (15/48)、77.1％ (37/48),정상이선조직표본중PTEN、Survivin표체양성솔분별위66.7％(10/15)、0(0/15),량자비교차이유통계학의의(P＜0.05)；이선암조직중PETN、Survivin적표체여환자적성별、년령균무관(P＞0.05),여암세포분화정도、림파결전이급TNM분기유관(P＜0.05).Survivin여PETN재이선암조직중적표체정부상관(r=- 0.381,P＜0.05).결론 Survivin 적이상고수평표체급PTEN적표체결실여이선암적발생、발전、전이급침윤밀절상관.
Objective To investigate the expression of PTEN and Survivin in pancreatic cancer tissues and normal pancreatic tissues and the role of PTEN and Survivin in development of pancreatic cancer.Methods Two -pass immunhistochemistry was used to detect the expression of PTEN and Survivin in pancreatic cancer tissues of 48 patients and normal pancreatic tissues of 15 patients.Results The expressions of Survivin was significantly higher in cancer (77.1％ ) than those in normal tissues (0％).The expressions of PTEN was significantly lower in cancer( 31.3％ ) than those in normal tissues (66.7％ ).The expressions were correlated with carcinoma differentiation,lymph node metastasis and TNM stage in pancreatic carcinoma,and not correlated with gender and age of patients.The expression of Survivin in esophageal squamous cell carcinoma was negatively related to expression of PETN.Conclusions The abnormal high expression of Survivin and the loss of expression of PTEN are closely related to the occurrence,development,metastasis and invasion of pancreatic carcinoma.
