中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
14期
980-983
,共4页
纪宏文%马丽%高旭蓉%刘娜%张颖%王杨%马祖轩%王跃%王静%富新%熊乾%齐虹美
紀宏文%馬麗%高旭蓉%劉娜%張穎%王楊%馬祖軒%王躍%王靜%富新%熊乾%齊虹美
기굉문%마려%고욱용%류나%장영%왕양%마조헌%왕약%왕정%부신%웅건%제홍미
血栓弹力描记术%参考值%北京%中国
血栓彈力描記術%參攷值%北京%中國
혈전탄력묘기술%삼고치%북경%중국
Thromboelastography%Reference values%Beijing%China
目的 测定北京地区常住中国成年居民健康志愿者血栓弹力图(TEG)数据,建立正常参考值,并与试剂厂家提供的正常值进行比较.方法 2010年6-8月采集健康成年志愿者静脉血4 ml,分别测定TEG和凝血4项.TEG检测:应用Haemoscope 5000分别测定凝血反应时间(R)、凝血形成时间(K)、凝固角(α-Angle)、最大振幅(MA)、纤维蛋白溶解率(LY30)和凝血指数(CI).凝血4项检测包括:凝血酶原时间(PT)、激活部分凝血致活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原.结果 137名志愿者TEG各参数正常参考值分别为R:3.8～8.4 min,K:0.8～3.3 min,α-Angle:46.2～76.2°,MA:50.0～70.8 mm,LY30:-3.3%～4.0%,CI:-3.8～2.9.24.1%(33/137)的健康志愿者至少一项参数超出厂家提供的正常范围,约有7.3%(10/137)的健康人被诊断为凝血异常,其检测的特异性为76.0%.与西方人参考范围(厂家提供的)比较,中国人健康志愿者的α-Angle低.男女性别间分组比较,R、K、α-Angle、MA和CI组间差异均有统计学意义(均P＜0.01).结论 TEG检测实验室有必要根据检测人群特点建立自己的正常参考值.
目的 測定北京地區常住中國成年居民健康誌願者血栓彈力圖(TEG)數據,建立正常參攷值,併與試劑廠傢提供的正常值進行比較.方法 2010年6-8月採集健康成年誌願者靜脈血4 ml,分彆測定TEG和凝血4項.TEG檢測:應用Haemoscope 5000分彆測定凝血反應時間(R)、凝血形成時間(K)、凝固角(α-Angle)、最大振幅(MA)、纖維蛋白溶解率(LY30)和凝血指數(CI).凝血4項檢測包括:凝血酶原時間(PT)、激活部分凝血緻活酶時間(APTT)、凝血酶時間(TT)和纖維蛋白原.結果 137名誌願者TEG各參數正常參攷值分彆為R:3.8～8.4 min,K:0.8～3.3 min,α-Angle:46.2～76.2°,MA:50.0～70.8 mm,LY30:-3.3%～4.0%,CI:-3.8～2.9.24.1%(33/137)的健康誌願者至少一項參數超齣廠傢提供的正常範圍,約有7.3%(10/137)的健康人被診斷為凝血異常,其檢測的特異性為76.0%.與西方人參攷範圍(廠傢提供的)比較,中國人健康誌願者的α-Angle低.男女性彆間分組比較,R、K、α-Angle、MA和CI組間差異均有統計學意義(均P＜0.01).結論 TEG檢測實驗室有必要根據檢測人群特點建立自己的正常參攷值.
목적 측정북경지구상주중국성년거민건강지원자혈전탄력도(TEG)수거,건립정상삼고치,병여시제엄가제공적정상치진행비교.방법 2010년6-8월채집건강성년지원자정맥혈4 ml,분별측정TEG화응혈4항.TEG검측:응용Haemoscope 5000분별측정응혈반응시간(R)、응혈형성시간(K)、응고각(α-Angle)、최대진폭(MA)、섬유단백용해솔(LY30)화응혈지수(CI).응혈4항검측포괄:응혈매원시간(PT)、격활부분응혈치활매시간(APTT)、응혈매시간(TT)화섬유단백원.결과 137명지원자TEG각삼수정상삼고치분별위R:3.8～8.4 min,K:0.8～3.3 min,α-Angle:46.2～76.2°,MA:50.0～70.8 mm,LY30:-3.3%～4.0%,CI:-3.8～2.9.24.1%(33/137)적건강지원자지소일항삼수초출엄가제공적정상범위,약유7.3%(10/137)적건강인피진단위응혈이상,기검측적특이성위76.0%.여서방인삼고범위(엄가제공적)비교,중국인건강지원자적α-Angle저.남녀성별간분조비교,R、K、α-Angle、MA화CI조간차이균유통계학의의(균P＜0.01).결론 TEG검측실험실유필요근거검측인군특점건립자기적정상삼고치.
Objective To determine the normal values for thromboelastography (TEG) in Chinese healthy adult volunteers residing in Beijing for over three years and compare them with those of the manufacturer's. Methods A total of 137 healthy adult volunteers were enrolled from June 2010 to August 2010. The technique was standardized with citrated blood and kaolin activator. And a Haemoscope 5000 device was employed. The TEG parameters analyzed were R, K, α, maximal amplitude ( MA), LY30 and coagulation index ( CI). All volunteers underwent the tests of prothrombin time ( PT), activated partial thromboplastin time (APTT), thrombin time (TT) and plasma fibrinogen level with the same blood sample. Results The reference ranges of 95% for 137 volunteers were R:3.8 - 8.4 min, K:0. 8 - 3.3min, α-Angle:46.2 -76.2°, MA: 50.0-70.8 mm, LY30: -3.3% -4.0% and CI: -3.8 -2.9.Overall, 24. 1% (33/137) of the volunteers had at least one abnormal parameter while 7.3% (10/137)would have been considered coagulopathy had the manufacturer's reference values been used, resulting in a test specificity of 76.0%. As compared with the western ethnicity ( the manufacturer's reference values),Chinese healthy volunteers were associated with lower fibrinogen functions. There were significantly diffenrent in R, K, α-Angle, MA and CI bettween men and women groups( all P ＜0. 01 ). Conclusion This study supports the manufacturer's recommendation that each institute should determine its own normal reference values.
