中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2010年
7期
715-718
,共4页
葛庆波%罗巧云%李静%方昭庚%王真真%刘志红
葛慶波%囉巧雲%李靜%方昭庚%王真真%劉誌紅
갈경파%라교운%리정%방소경%왕진진%류지홍
糖化血红蛋白%脑梗死%血糖%糖尿病
糖化血紅蛋白%腦梗死%血糖%糖尿病
당화혈홍단백%뇌경사%혈당%당뇨병
Glycosylated hemoglobin%Cerebral infarction%Blood sugar%Diabetes
目的 探讨急性脑梗死患者与正常对照组糖化血红蛋白(HbA1c)含量的差异,脑梗死患者HbA1c含量与其神经功能缺损程度评分的相关性以及影像学中脑梗死病灶数与HbA1c含量间的关系.方法 选取186例发病1周内的急性脑梗死患者,入院后行神经功能缺损程度评分,人院24 h内空腹查FibAlc,发病或病情稳定48 h后查颅脑MRI,脑梗死恢复期行葡萄糖耐量检查.同时对160名健康体检者抽空腹血查HbA1c、行葡萄糖耐量实验.观察脑梗死患者与健康体检者HbA1c水平的差异.脑梗死患者HbA1c含量与其神经功能缺损程度评分的相关性以及HbA1c含量与脑梗死病灶个数的关系.结果急性脑梗死患者HbA1c水平(6.982%±1.803%)较对照组(5.128%±0.592%)增高,比较差异有统计学意义(P<0.05);脑梗死患者血中HbA1c含量与其神经功能缺损程度评分呈正相关(r=0.760,P<0.05);2个脑梗死病灶组HbA1c含量(6.635%±0.427%)与1个病灶组(5.803%±0_307%)比较差异有统计学意义(P<0.05),3个及3个以上病灶组HbA1c含量(8.571%±0.519%)分别与1个病灶组、2个病灶组比较差异有统计学意义(P<0.05).结论 糖尿病是脑梗死的重要危险因素,较高水平的HbA1c引起的一系列脑血管病理改变是脑梗死事件发生的重要冈素.HbA1c水平也是早期对病情严重程度评估的一个重要指标,积极控制高血糖、降低HbA1c水平有助于减少脑梗死事件的发生.
目的 探討急性腦梗死患者與正常對照組糖化血紅蛋白(HbA1c)含量的差異,腦梗死患者HbA1c含量與其神經功能缺損程度評分的相關性以及影像學中腦梗死病竈數與HbA1c含量間的關繫.方法 選取186例髮病1週內的急性腦梗死患者,入院後行神經功能缺損程度評分,人院24 h內空腹查FibAlc,髮病或病情穩定48 h後查顱腦MRI,腦梗死恢複期行葡萄糖耐量檢查.同時對160名健康體檢者抽空腹血查HbA1c、行葡萄糖耐量實驗.觀察腦梗死患者與健康體檢者HbA1c水平的差異.腦梗死患者HbA1c含量與其神經功能缺損程度評分的相關性以及HbA1c含量與腦梗死病竈箇數的關繫.結果急性腦梗死患者HbA1c水平(6.982%±1.803%)較對照組(5.128%±0.592%)增高,比較差異有統計學意義(P<0.05);腦梗死患者血中HbA1c含量與其神經功能缺損程度評分呈正相關(r=0.760,P<0.05);2箇腦梗死病竈組HbA1c含量(6.635%±0.427%)與1箇病竈組(5.803%±0_307%)比較差異有統計學意義(P<0.05),3箇及3箇以上病竈組HbA1c含量(8.571%±0.519%)分彆與1箇病竈組、2箇病竈組比較差異有統計學意義(P<0.05).結論 糖尿病是腦梗死的重要危險因素,較高水平的HbA1c引起的一繫列腦血管病理改變是腦梗死事件髮生的重要岡素.HbA1c水平也是早期對病情嚴重程度評估的一箇重要指標,積極控製高血糖、降低HbA1c水平有助于減少腦梗死事件的髮生.
목적 탐토급성뇌경사환자여정상대조조당화혈홍단백(HbA1c)함량적차이,뇌경사환자HbA1c함량여기신경공능결손정도평분적상관성이급영상학중뇌경사병조수여HbA1c함량간적관계.방법 선취186례발병1주내적급성뇌경사환자,입원후행신경공능결손정도평분,인원24 h내공복사FibAlc,발병혹병정은정48 h후사로뇌MRI,뇌경사회복기행포도당내량검사.동시대160명건강체검자추공복혈사HbA1c、행포도당내량실험.관찰뇌경사환자여건강체검자HbA1c수평적차이.뇌경사환자HbA1c함량여기신경공능결손정도평분적상관성이급HbA1c함량여뇌경사병조개수적관계.결과급성뇌경사환자HbA1c수평(6.982%±1.803%)교대조조(5.128%±0.592%)증고,비교차이유통계학의의(P<0.05);뇌경사환자혈중HbA1c함량여기신경공능결손정도평분정정상관(r=0.760,P<0.05);2개뇌경사병조조HbA1c함량(6.635%±0.427%)여1개병조조(5.803%±0_307%)비교차이유통계학의의(P<0.05),3개급3개이상병조조HbA1c함량(8.571%±0.519%)분별여1개병조조、2개병조조비교차이유통계학의의(P<0.05).결론 당뇨병시뇌경사적중요위험인소,교고수평적HbA1c인기적일계렬뇌혈관병리개변시뇌경사사건발생적중요강소.HbA1c수평야시조기대병정엄중정도평고적일개중요지표,적겁공제고혈당、강저HbA1c수평유조우감소뇌경사사건적발생.
Objective To investigate the differences of blood glycosylated hemoglobin (HbA1c) levels between the patients with acute cerebral infarction and healthy controls, and explore the relation between HbA1c level and both neurological deficits scores and imaging of lesions in number. Methods One hundred and eighty-six patients with acute cerebral infarction within 1 week were performed neurological deficits scales after the admission; the HbA1c level was measured within 24 h admission; brain MRI scan was performed on these patients 48 h after onset or stabilization. Glucose tolerance test was taken at the rehabilitation of infarction (except for having a clear history of diabetes before). At the same time, 160 healthy controls were checked on the level of HbA1c and taken the glucose tolerance test. The differences of blood HbA1c levels between the patients with acute cerebral infarction and healthy controls were investigated; and the relation between HbA1c level and both neurological deficits scores and imaging of lesions in number was explored. Results The HbA1c level in patients with acute cerebral infarction (6.982%±1.803%) was significantly higher than that in the controls (5.128%±0.592%, P<0.05). The level of HbA1c in patients with cerebral infarction and the neurological deficits scores were positively correlated (r=0.760, P<0.05). The level of HbA1c in patients with 2 lesions (6.635%±0.427%) was obviously higher than that in patients with 1 lesion (5.803%±0.307%, P<0.05); The level of HbA1c in patients with 3 or more lesions (8.571%±0.519%) was obviously higher than that in patients with 1 or 2 lesions (P<0.05). Conclusion Diabetes is a major risk factor for cerebral infarction. High HbA1c level might cause a series of cerebrovascular diseases, thus it is an important factor in the happening of cerebral infarction and HbA1c level is an important indicator of the early assessment of the severity of the diseases. The incidence of cerebral infarction can be decreased by controlling hyperglycaemia, lowering the HbA1c levels.
