CAJ | 학술논문

目的探讨维生素E治疗对脑梗死患者血液中低密度脂蛋白体外氧化延迟时间的影响.方法选取22例脑梗死患者作为治疗组.给予维生素E(300mg/d)治疗;选取22例年龄、性别、血压、病灶部位及程度与治疗组相当的腩梗死患者作为对照组,小给予维生素E治疗.收集患者发病24 h以内和发病2周时血清,测定血样中低密度脂蛋白体外氧化延迟时间,同时测定血清中维牛素E浓度,低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇.结果治疗组患者2周时血样中低密度脂蛋白体外氧化延迟时间明显长于对照组[(71.84±9.75)min vs(60.95±9.33)min],差异有统计学意义(P<0.05).血清中维牛素E的浓度明显高于对照组[(17.41±5.24)ìmol/L vs(12.90±6.27)ìmol/L],差异有统计学意义(P<0.05),且与卒中症候呈现负相关趋势.治疗组与对照组静脉血中低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇差异无统计学意义[分别为(5.08±0.61)vs(4.72±0.61)mmol/L;(0.88±0.06)mmol/Lvs (0.84±0.03)mmol/L;(1.62±0.41)vs(1.65±0.92)mmol/L].结论给予维生素E治疗可以增加急性期脑梗死患者血液中低密度脂蛋白体外氧化延迟时间,增强患者体内的抗氧化能力.
목적 탐토유생소E치료대뇌경사환자혈액중저밀도지단백체외양화연지시간적영향.방법 선취22례뇌경사환자작위치료조.급여유생소E(300mg/d)치료;선취22례년령、성별、혈압、병조부위급정도여치료조상당적남경사환자작위대조조,소급여유생소E치료.수집환자발병24 h이내화발병2주시혈청,측정혈양중저밀도지단백체외양화연지시간,동시측정혈청중유우소E농도,저밀도지단백중적총담고순、삼선감유、유리담고순.결과 치료조환자2주시혈양중저밀도지단백체외양화연지시간명현장우대조조[(71.84±9.75)min vs(60.95±9.33)min],차이유통계학의의(P<0.05).혈청중유우소E적농도명현고우대조조[(17.41±5.24)ìmol/L vs(12.90±6.27)ìmol/L],차이유통계학의의(P<0.05),차여졸중증후정현부상관추세.치료조여대조조정맥혈중저밀도지단백중적총담고순、삼선감유、유리담고순차이무통계학의의[분별위(5.08±0.61)vs(4.72±0.61)mmol/L;(0.88±0.06)mmol/Lvs (0.84±0.03)mmol/L;(1.62±0.41)vs(1.65±0.92)mmol/L].결론급여유생소E치료가이증가급성기뇌경사환자혈액중저밀도지단백체외양화연지시간,증강환자체내적항양화능력.
Objective To investigate the effect of vitamin E on the lag time of serum low-density lipoprotein (LDL) oxidation in vitro in patients with acute cerebral infarction (ACI). Methods Twenty-two patients with ACI received vitamin E treatment at the dose of 300 mg/day, and another 22 ACI patients matched for age, gender ratio, blood pressure, blood lipid level, location and degree of the infarction served as the control group in which no vitamin E was given. Serum samples were collected from the patients within 24 h and at 2 weeks after the onset to test the lag time of LDL oxidation in vitro and measure the levels of vitamin E, total cholesterol, triglyceride and free cholesterol. Results At two weeks after the onset of the infarction, the patients receiving vitamin E treatment had significantly prolonged lag time of LDL oxidation in comparison with that of the control patients (71.84± 9.75 vs 60.95±9.33 min, P<0.05), and showed also significantly higher vitamin E level in the serum Vitamin E and stroke index. The two groups of patients showed no significant differences in total cholesterol (5.08cholesterol (1.62oxidation in vitro is prolonged in ACI patients with vitamin E treatment, suggesting that vitamin E can increase the resistance of the patients against anti-oxidative stress.