CAJ | 학술논문

目的分析1960-2006年间从浅部真菌感染病例中分离所得致病菌的情况.方法归类、统计1960年1月至2006年12月(1991年9月至1992年7月缺如)期间华中科技大学同济医学院附属协和医院皮肤性病科真菌室分离鉴定自皮肤、黏膜浅部真菌感染中的病原真菌.标本来自全院各临床科室门诊、住院患者、湖北省地县及邻近省市有关医院.鉴定方法包括形态学、生理及生化实验方法.结果菌株合计11 989株,鉴定出23个种,16个属.可分为皮肤癣菌、念珠菌及酵母菌(含马拉色菌)、非皮肤癣菌之丝状真菌3大类.除去可能为污染菌的非皮肤癣菌之丝状真菌(287株)外,其余11 702株菌中,以念珠菌(5642株,48.2％)和皮肤癣菌(5279株,45.1％)为主,酵母菌占3.8％( 449株),马拉色菌占2.8％(332株).在种属水平上排序,菌株数处于前3位的真菌种类依次为红色毛癣菌(3865株,33.0％)、白念球菌(3110株,26.6％)和非白念珠菌(2532株,21.6％).皮肤癣菌分离自掌跖、指趾间以外光滑皮肤损害的最多(1787/5279,占37.7％),数量最多的为红色毛癣菌,其次为紫色毛癣菌.念珠菌大多分离自黏膜部位(4099/5642,72.7％),白念珠菌数量占第1位.结论 1960-2006年间从浅部真菌感染中分离所得致病菌以念珠菌和皮肤癣菌为主,红色毛癣菌数量最多.
목적 분석1960-2006년간종천부진균감염병례중분리소득치병균적정황.방법 귀류、통계1960년1월지2006년12월(1991년9월지1992년7월결여)기간화중과기대학동제의학원부속협화의원피부성병과진균실분리감정자피부、점막천부진균감염중적병원진균.표본래자전원각림상과실문진、주원환자、호북성지현급린근성시유관의원.감정방법포괄형태학、생리급생화실험방법.결과 균주합계11 989주,감정출23개충,16개속.가분위피부선균、념주균급효모균(함마랍색균)、비피부선균지사상진균3대류.제거가능위오염균적비피부선균지사상진균(287주)외,기여11 702주균중,이념주균(5642주,48.2％)화피부선균(5279주,45.1％)위주,효모균점3.8％( 449주),마랍색균점2.8％(332주).재충속수평상배서,균주수처우전3위적진균충류의차위홍색모선균(3865주,33.0％)、백념구균(3110주,26.6％)화비백념주균(2532주,21.6％).피부선균분리자장척、지지간이외광활피부손해적최다(1787/5279,점37.7％),수량최다적위홍색모선균,기차위자색모선균.념주균대다분리자점막부위(4099/5642,72.7％),백념주균수량점제1위.결론 1960-2006년간종천부진균감염중분리소득치병균이념주균화피부선균위주,홍색모선균수량최다.
Objective To analyze fungal isolates from patients with superficial fungal infections during 1960-2006.Methods Fungal strains isolated from patients with superficial (mucocutaneous and cutaneous)fungal infections and identified in the Medical Mycology Clinical Laboratory,Department of Dermatology and Venereology,Union Hospital,from 1960 to 2006 (data from September 1991 to July 1992 were unavailable),were subjected to a classification and statistical analysis.Clinical samples for mycological examination were taken from outpatients or inpatients of different departments in hospitals of Hubei province and surrounding areas.Morphological,physiological and biochemical methods were applied for species identification.Results A total of 11 989 Candida strains were isolated,which belonged to 23 species and 16 genera.They fell into 3 groups,i.e.,dermatophytes,Candida and yeasts (including Malassezia),and non-dermatophyte moulds.Since 287 strains of moulds were suspected to be contaminating fungi,11 702 residual isolates were analyzed.Of the analyzed isolates,Candida species (5642/11 702,48.2％ )and dermatophytes (5279/11 702,45.1％ )predominated,followed by yeasts (449/11 702,3.8％) and Malassezia species (332/11 702,2.8％).The most frequently isolated species was Trichophyton rubrum (3865/11 702,33.0％),Candida albicans (3110/11 702,26.6％ ) and non-albicans Candida species (2532/11 702,21.6％ ).Dermatophyte strains were mostly isolated from lesions of smooth skin with an exception of palmoplantar and interdigit regions (1787/5279,37.7％).The most common dermatophyte species was Trichophyton rubrum,followed by Trichophyton violanceum.Candida was mainly isolated from mucous membrane lesions (4099/5642,72.7％),with Candida albicans being the predominant species.Conclusions Candida species and dermatophytes predominate in patients with superficial fungal infections during 1960-2006,with Trichophyton rubrum being the most common species.