中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2010年
3期
156-160
,共5页
储康康%洪珊珊%柯晓燕%汤天宇%邹冰%李慧国%杭跃跃%张久平%阮宗才%周振宇%陆祖宏
儲康康%洪珊珊%柯曉燕%湯天宇%鄒冰%李慧國%杭躍躍%張久平%阮宗纔%週振宇%陸祖宏
저강강%홍산산%가효연%탕천우%추빙%리혜국%항약약%장구평%원종재%주진우%륙조굉
孤独性障碍%磁共振成像,弥散%胼胝体%额叶%纤维跟踪
孤獨性障礙%磁共振成像,瀰散%胼胝體%額葉%纖維跟蹤
고독성장애%자공진성상,미산%변지체%액협%섬유근종
Autistic disorder%Diffusion magnetic resonance imaging%Corpus callosum%Frontal lobe%Fiber tractography
目的 对照分析高功能孤独障碍患儿与正常儿童胼胝体及额叶纤维结构的差异.方法 选取18例高功能孤独障碍患儿(病例组)和16名年龄、性别、智商、身高、体质量与之相匹配的正常儿童(对照组),进行头部弥散张量成像(diffusion tensor imaging,DTI)扫描.使用DTIStudio软件进行图像处理,计算并比较2组胼胝体各亚区及左、右额叶的各向异性分数(fractional anisotropy,FA)、表面扩散分数(apparent diffusion coefficient,ADC)、纤维数目及平均长度的差异.结果 与对照组相比,病例组胼胝体前1/3部的纤维数目显著下降[(839±193)条vs(630±203)条;F=9.419,P=0.004];纤维的平均长度、FA值的差异无统计学意义(P＞0.05);病例组胼胝体前1/3部纤维的ADC值显著增大[(0.88±8.56)×10-3 mm2/s vs(0.94±6.98)×10-3 mm2/s;F=5.739,P=0.023].左、右大脑额叶长、短纤维的FA值均较对照组显著减小(F=10.109,P=0.003;F=9.186,P=0.005),长程纤维的ADC值显著增加(F=6.154,P=0.019;F=6.814,P=0.014).结论 高功能孤独障碍儿童胼胝体前1/3部纤维减少最明显,额叶与其他脑区之间呈现低连通性.
目的 對照分析高功能孤獨障礙患兒與正常兒童胼胝體及額葉纖維結構的差異.方法 選取18例高功能孤獨障礙患兒(病例組)和16名年齡、性彆、智商、身高、體質量與之相匹配的正常兒童(對照組),進行頭部瀰散張量成像(diffusion tensor imaging,DTI)掃描.使用DTIStudio軟件進行圖像處理,計算併比較2組胼胝體各亞區及左、右額葉的各嚮異性分數(fractional anisotropy,FA)、錶麵擴散分數(apparent diffusion coefficient,ADC)、纖維數目及平均長度的差異.結果 與對照組相比,病例組胼胝體前1/3部的纖維數目顯著下降[(839±193)條vs(630±203)條;F=9.419,P=0.004];纖維的平均長度、FA值的差異無統計學意義(P＞0.05);病例組胼胝體前1/3部纖維的ADC值顯著增大[(0.88±8.56)×10-3 mm2/s vs(0.94±6.98)×10-3 mm2/s;F=5.739,P=0.023].左、右大腦額葉長、短纖維的FA值均較對照組顯著減小(F=10.109,P=0.003;F=9.186,P=0.005),長程纖維的ADC值顯著增加(F=6.154,P=0.019;F=6.814,P=0.014).結論 高功能孤獨障礙兒童胼胝體前1/3部纖維減少最明顯,額葉與其他腦區之間呈現低連通性.
목적 대조분석고공능고독장애환인여정상인동변지체급액협섬유결구적차이.방법 선취18례고공능고독장애환인(병례조)화16명년령、성별、지상、신고、체질량여지상필배적정상인동(대조조),진행두부미산장량성상(diffusion tensor imaging,DTI)소묘.사용DTIStudio연건진행도상처리,계산병비교2조변지체각아구급좌、우액협적각향이성분수(fractional anisotropy,FA)、표면확산분수(apparent diffusion coefficient,ADC)、섬유수목급평균장도적차이.결과 여대조조상비,병례조변지체전1/3부적섬유수목현저하강[(839±193)조vs(630±203)조;F=9.419,P=0.004];섬유적평균장도、FA치적차이무통계학의의(P＞0.05);병례조변지체전1/3부섬유적ADC치현저증대[(0.88±8.56)×10-3 mm2/s vs(0.94±6.98)×10-3 mm2/s;F=5.739,P=0.023].좌、우대뇌액협장、단섬유적FA치균교대조조현저감소(F=10.109,P=0.003;F=9.186,P=0.005),장정섬유적ADC치현저증가(F=6.154,P=0.019;F=6.814,P=0.014).결론 고공능고독장애인동변지체전1/3부섬유감소최명현,액협여기타뇌구지간정현저련통성.
Objective To detect the fiber structure differences in the corpus callosum and frontal lobe between autism children with high functioning (HFA) and the healthy children. Methods Diffusion tensor image were obtained in 18 HFA patients and 16 normal controls matched with age, sex, intelligent quotient, height and weight. The differences of fiber fractional anisotropy ( FA), fiber apparent diffusion coefficient (ADC), fiber number, average fiber length of the subregions of corpus callosum and the frontal lobe between the two groups were measured by the software of DTIStudio. Results Compared with the control group, the fiber number in the HFA group had a significant decrease in anterior third [ (839 ± 193)vs (630 ±203) ;F =9. 419, P =0. 004]. There was no significant difference in FA value and average fiber length (P ＞ 0. 05). ADC value of the HFA group had a significant increase in anterior third [ (0. 88 ±8.56) x 10-3 mm2/s vs (0. 94 ±6. 98) × 10-3 mm2/s;F =5. 739, P =0. 023], in HFA group's left and right frontal lobes, the FA values were significantly decreased (F = 10. 109, P = 0.003;F = 9. 186,P = 0. 005 ) and the ADC values of long range fibers were significantly increased ( F = 6. 154, P = 0. 019;F = 6. 814, P = 0. 014). Conclusion The results indicate the fibers in anterior third of corpus callosum significantly decrease in autism children with high functioning, which implies low connectivity between the frontal and other lobes.
