国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2010年
22期
1362-1364
,共3页
陈晖%刁鑫%王丽娜%张彦兵%王胜昱
陳暉%刁鑫%王麗娜%張彥兵%王勝昱
진휘%조흠%왕려나%장언병%왕성욱
凋亡抑制蛋白%Livin%非小细胞肺癌
凋亡抑製蛋白%Livin%非小細胞肺癌
조망억제단백%Livin%비소세포폐암
Inhibitor of apoptosis protein%Livin%Non-small cell lung cancer
目的 通过检测凋亡抑制蛋白Livin在非小细胞肺癌患者、肺炎患者及健康者血清中的含量,探讨Livin对于诊断非小细胞肺癌的临床意义.方法 采用酶联免疫吸附试验对85例非小细胞肺癌患者、20例肺炎患者、20名正常健康人血清Livin水平进行检测.结果 非小细胞肺癌组血清Livin水平表达最高,肺炎组次之,健康对照组最低.三组间具有显著差异(P＜0.001).血清Livin浓度随着肿瘤分期的升高而升高.Ⅲ～Ⅳ期非小细胞肺癌患者血清Livin水平高于Ⅰ～Ⅱ期患者(P＜0.05).结论 Livin作为一种凋亡抑制蛋白对非小细胞肺癌的诊断及判断患者预后具有一定的临床价值.
目的 通過檢測凋亡抑製蛋白Livin在非小細胞肺癌患者、肺炎患者及健康者血清中的含量,探討Livin對于診斷非小細胞肺癌的臨床意義.方法 採用酶聯免疫吸附試驗對85例非小細胞肺癌患者、20例肺炎患者、20名正常健康人血清Livin水平進行檢測.結果 非小細胞肺癌組血清Livin水平錶達最高,肺炎組次之,健康對照組最低.三組間具有顯著差異(P＜0.001).血清Livin濃度隨著腫瘤分期的升高而升高.Ⅲ～Ⅳ期非小細胞肺癌患者血清Livin水平高于Ⅰ～Ⅱ期患者(P＜0.05).結論 Livin作為一種凋亡抑製蛋白對非小細胞肺癌的診斷及判斷患者預後具有一定的臨床價值.
목적 통과검측조망억제단백Livin재비소세포폐암환자、폐염환자급건강자혈청중적함량,탐토Livin대우진단비소세포폐암적림상의의.방법 채용매련면역흡부시험대85례비소세포폐암환자、20례폐염환자、20명정상건강인혈청Livin수평진행검측.결과 비소세포폐암조혈청Livin수평표체최고,폐염조차지,건강대조조최저.삼조간구유현저차이(P＜0.001).혈청Livin농도수착종류분기적승고이승고.Ⅲ～Ⅳ기비소세포폐암환자혈청Livin수평고우Ⅰ～Ⅱ기환자(P＜0.05).결론 Livin작위일충조망억제단백대비소세포폐암적진단급판단환자예후구유일정적림상개치.
Objective To investigate the clinical significance of Livin in the diagnosis of non-small cell lung cancer (NSCLC) through testing the content of inhibitor of apoptosis protein Livin in the serum of NSCLC patients, pneumonia patients and healthy persons. Methods Livin levels in the serum of 85 NSCLC patients, 20 pneumonia patients and 20 healthy persons were detected by enzyme linked immunosorbent assay. Results Livin level in the serum of NSCLC patients was significantly higher than that in pneumonia patients and healthy persons. The serum Livin level was increased following with tumor progress. Livin level in NSCLC patients with stage Ⅲ-Ⅳ was higher than that in NSCLC patients with stage Ⅰ - Ⅱ ( P ＜0.05) . Conclusions As an inhibitor of apoptosis protein,Livin has certain clinical value on the diagnosis and prognosis judgement of NSCLC patients.
