中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2008年
3期
185-188
,共4页
子宫内膜异位症%脂类%钙%磷%性腺甾类激素
子宮內膜異位癥%脂類%鈣%燐%性腺甾類激素
자궁내막이위증%지류%개%린%성선치류격소
Endometriosis%Lipids%Calcium%Phosphorus%Gonadal steroid hormones
目的 探讨子宫内膜异位症(内异症)患者血脂和钙磷代谢的变化及其与内异症发病的关系.方法 回顾性分析223例内异症患者(其中年龄≤35岁148例,为内异症A组;＞35岁75例,为内异症B组)和200例非内异症患者(其中年龄≤35岁129例,为对照A组;＞35岁71例,为对照B组)的临床资料.应用电化学发光免疫分析法检测两组患者血清黄体生成素(LH)、卵泡刺激素(FSH)、睾酮、雌二醇和孕酮的水平;采用光电比色法检测血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、钙磷水平.结果 内异症A组和B组平均血清孕酮水平分别为2.0 nmol/L和1.8 nmol/L,均显著高于对照A组和B组的1.6 nmol/L和1.2 nmol/L,差异有统计学意义(P＜0.01);内异症B组血清LH水平为7.2 U/L,也显著高于对照B组的6.1 U/L,差异也有统计学意义(P＜0.01);而内异症A组血清LH水平(7.0 U/L)与对照A组(6.5 U/L)比较,差异无统计学意义(P＞0.05).内异症A组血清FSH、睾酮和雌二醇水平分别为6.2 U/L、1.1 nmol/L和269 pmol/L,与对照A组(6.3 U/L、1.1 nmol/L、264 pmol/L)分别比较,差异均无统计学意义(P＞0.05);内异症B组血清FSH、睾酮和雌二醇水平分别为6.6 U/L、1.0 nmol/L和345 pmol/L,与对照B组(6.6 U/L、0.9 nmol/L和279 pmol/L)比较,差异无统计学意义(P＞0.05).内异症A组和B组血清TG水平分别为0.71 mmol/L和0.72 mmol/L,均显著低于对照A组和B组的0.92 mmol/L和1.08 mmol/L,差异有统计学意义(P＜0.01);内异症A组和B组血清LDL水平分别为(2.2±0.5)mmol/L和(2.4±0.7)mmol/L,也均显著低于对照A组和B组[(2.4±0.6)mmol/L和(2.6±0.6)mmol/L],差异也有统计学意义(P＜0.01);而内异症A组和B组患者血清HDL水平[(1.62±0.31)mmol/L和(1.53±0.32)mmol/L]却均显著高于对照A组和B组[(1.48±0.21)mmol/L和(1.37±0.22)mmol/L],差异也有统计学意义(P＜0.01).但内异症A组和B组血清TC水平[(4.2±0.7)mmol/L和(4.4±0.8)mmol/L]与相应年龄段的对照A组和B组[(4.3±0.7)mmol/L和(4.5±0.7)mmol/L]比较,差异均无统计学意义(P＞0.05).另外,内异症A组和B组血磷水平[(1.01±0.22)mmol/L和(0.89±0.18)mmol/L]均显著低于对照A组和B组[(1.23±0.24)mmol/L和(1.10±0.13)mmol/L],差异有统计学意义(P＜0.01);而内异症A组和B组血钙水平[(2.39±0.23)mmol/L和(2.40±0.28)mmol/L]与相应年龄段的对照A组和B组[(2.41±0.12)mmol/L和(2.42±0.20)mmol/L]比较,差异均无统计学意义(P＞0.05).结论 内异症患者存在血脂和钙磷代谢的变化,血清高孕激素水平可能与内异症发病有关.
目的 探討子宮內膜異位癥(內異癥)患者血脂和鈣燐代謝的變化及其與內異癥髮病的關繫.方法 迴顧性分析223例內異癥患者(其中年齡≤35歲148例,為內異癥A組;＞35歲75例,為內異癥B組)和200例非內異癥患者(其中年齡≤35歲129例,為對照A組;＞35歲71例,為對照B組)的臨床資料.應用電化學髮光免疫分析法檢測兩組患者血清黃體生成素(LH)、卵泡刺激素(FSH)、睪酮、雌二醇和孕酮的水平;採用光電比色法檢測血清甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、鈣燐水平.結果 內異癥A組和B組平均血清孕酮水平分彆為2.0 nmol/L和1.8 nmol/L,均顯著高于對照A組和B組的1.6 nmol/L和1.2 nmol/L,差異有統計學意義(P＜0.01);內異癥B組血清LH水平為7.2 U/L,也顯著高于對照B組的6.1 U/L,差異也有統計學意義(P＜0.01);而內異癥A組血清LH水平(7.0 U/L)與對照A組(6.5 U/L)比較,差異無統計學意義(P＞0.05).內異癥A組血清FSH、睪酮和雌二醇水平分彆為6.2 U/L、1.1 nmol/L和269 pmol/L,與對照A組(6.3 U/L、1.1 nmol/L、264 pmol/L)分彆比較,差異均無統計學意義(P＞0.05);內異癥B組血清FSH、睪酮和雌二醇水平分彆為6.6 U/L、1.0 nmol/L和345 pmol/L,與對照B組(6.6 U/L、0.9 nmol/L和279 pmol/L)比較,差異無統計學意義(P＞0.05).內異癥A組和B組血清TG水平分彆為0.71 mmol/L和0.72 mmol/L,均顯著低于對照A組和B組的0.92 mmol/L和1.08 mmol/L,差異有統計學意義(P＜0.01);內異癥A組和B組血清LDL水平分彆為(2.2±0.5)mmol/L和(2.4±0.7)mmol/L,也均顯著低于對照A組和B組[(2.4±0.6)mmol/L和(2.6±0.6)mmol/L],差異也有統計學意義(P＜0.01);而內異癥A組和B組患者血清HDL水平[(1.62±0.31)mmol/L和(1.53±0.32)mmol/L]卻均顯著高于對照A組和B組[(1.48±0.21)mmol/L和(1.37±0.22)mmol/L],差異也有統計學意義(P＜0.01).但內異癥A組和B組血清TC水平[(4.2±0.7)mmol/L和(4.4±0.8)mmol/L]與相應年齡段的對照A組和B組[(4.3±0.7)mmol/L和(4.5±0.7)mmol/L]比較,差異均無統計學意義(P＞0.05).另外,內異癥A組和B組血燐水平[(1.01±0.22)mmol/L和(0.89±0.18)mmol/L]均顯著低于對照A組和B組[(1.23±0.24)mmol/L和(1.10±0.13)mmol/L],差異有統計學意義(P＜0.01);而內異癥A組和B組血鈣水平[(2.39±0.23)mmol/L和(2.40±0.28)mmol/L]與相應年齡段的對照A組和B組[(2.41±0.12)mmol/L和(2.42±0.20)mmol/L]比較,差異均無統計學意義(P＞0.05).結論 內異癥患者存在血脂和鈣燐代謝的變化,血清高孕激素水平可能與內異癥髮病有關.
목적 탐토자궁내막이위증(내이증)환자혈지화개린대사적변화급기여내이증발병적관계.방법 회고성분석223례내이증환자(기중년령≤35세148례,위내이증A조;＞35세75례,위내이증B조)화200례비내이증환자(기중년령≤35세129례,위대조A조;＞35세71례,위대조B조)적림상자료.응용전화학발광면역분석법검측량조환자혈청황체생성소(LH)、란포자격소(FSH)、고동、자이순화잉동적수평;채용광전비색법검측혈청감유삼지(TG)、총담고순(TC)、저밀도지단백(LDL)、고밀도지단백(HDL)、개린수평.결과 내이증A조화B조평균혈청잉동수평분별위2.0 nmol/L화1.8 nmol/L,균현저고우대조A조화B조적1.6 nmol/L화1.2 nmol/L,차이유통계학의의(P＜0.01);내이증B조혈청LH수평위7.2 U/L,야현저고우대조B조적6.1 U/L,차이야유통계학의의(P＜0.01);이내이증A조혈청LH수평(7.0 U/L)여대조A조(6.5 U/L)비교,차이무통계학의의(P＞0.05).내이증A조혈청FSH、고동화자이순수평분별위6.2 U/L、1.1 nmol/L화269 pmol/L,여대조A조(6.3 U/L、1.1 nmol/L、264 pmol/L)분별비교,차이균무통계학의의(P＞0.05);내이증B조혈청FSH、고동화자이순수평분별위6.6 U/L、1.0 nmol/L화345 pmol/L,여대조B조(6.6 U/L、0.9 nmol/L화279 pmol/L)비교,차이무통계학의의(P＞0.05).내이증A조화B조혈청TG수평분별위0.71 mmol/L화0.72 mmol/L,균현저저우대조A조화B조적0.92 mmol/L화1.08 mmol/L,차이유통계학의의(P＜0.01);내이증A조화B조혈청LDL수평분별위(2.2±0.5)mmol/L화(2.4±0.7)mmol/L,야균현저저우대조A조화B조[(2.4±0.6)mmol/L화(2.6±0.6)mmol/L],차이야유통계학의의(P＜0.01);이내이증A조화B조환자혈청HDL수평[(1.62±0.31)mmol/L화(1.53±0.32)mmol/L]각균현저고우대조A조화B조[(1.48±0.21)mmol/L화(1.37±0.22)mmol/L],차이야유통계학의의(P＜0.01).단내이증A조화B조혈청TC수평[(4.2±0.7)mmol/L화(4.4±0.8)mmol/L]여상응년령단적대조A조화B조[(4.3±0.7)mmol/L화(4.5±0.7)mmol/L]비교,차이균무통계학의의(P＞0.05).령외,내이증A조화B조혈린수평[(1.01±0.22)mmol/L화(0.89±0.18)mmol/L]균현저저우대조A조화B조[(1.23±0.24)mmol/L화(1.10±0.13)mmol/L],차이유통계학의의(P＜0.01);이내이증A조화B조혈개수평[(2.39±0.23)mmol/L화(2.40±0.28)mmol/L]여상응년령단적대조A조화B조[(2.41±0.12)mmol/L화(2.42±0.20)mmol/L]비교,차이균무통계학의의(P＞0.05).결론 내이증환자존재혈지화개린대사적변화,혈청고잉격소수평가능여내이증발병유관.
Objective To investigate the metabolism of lipid,calcium and phosphorus in women with endometriosis.Methods Clinical data of 223 patients with endometriosis and 200 patients without endometriosis were retrospectively analyzed.Electrochemiluminoimmunoassay was used to detect the levels of serum luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),estradiol(E2)and progesterone(P),and photoelectric colorimetry was used to determine the concentrations of serum triglyceride ( TG), total cholesterol ( TC ), low density lipoprotein ( LDL), high density lipoprotein (HDL), calcium and phosphorus in the patients with and without endometriosis. Results The levels of serum P were 2. 0 nmol/L and 1.8 nmol/L in endometriosis patients with age≤35 years old (case group A)and ＞35 years old (case group B), and 1.6 nmol/L and 1.2 nmol/L in patients without endometriosis at age≤35 years old (control group A) and ＞ 35 years old (control group B), respectively. A significant difference was found between case group A and control group A, and between case group B and control group B. The levels of serum LH was significantly higher in case group B (7. 2 U/L) than that in control group B (6. 1 U/L), however, there was no significant difference between case group A (7. 0 U/L) and control group A (6. 5 U/L). Also no significant difference in serum FSH, T and E2 levels was found between case group A (respectively, 6.2 U/L,1.1 nmol/L and 269 pmol/L) and control group A (respectively, 6.3 U/L, 1.1nmol/L and 264 pmol/L), also between case group B (respectively, 6.6 U/L, 1.0 nmol/L and 345pmol/L) and control group B (6. 6 IU/L, 0. 9 nmol/L and 279 pmol/L). The concentrations of serum TG in case group A and B (0. 71 mmol/L and 0. 72 mmol/L) were significantly lower than in control group A and B (0. 92 mmol/L and 1.08 mmol/L), respectively. The concentrations of serum LDL in case group A and B [ (2. 2 ± 0. 5) mmol/L and (2.4 ± 0. 6) mmol/L]were also significantly lower than in control group A and B[ (2. 4 ± 0. 7) mmol/L and (2. 62 ±0. 63) mmol/L], respectively. However, the concentrations of serum HDL in case group A and B [ (1.62 ± 0. 31) mmol/L and(1.53 ± 0. 32) mmol/L] were significantly higher than in control group A and B [ ( 1.48 ± 0. 21 ) mmol/L and ( 1.37 ± 0.22) mmol/L], respectively.In addition, the concentrations of serum TC were not significantly different between case group A and control group A [ (4. 2 ± 0. 7) mmol/L and (4. 29 ± 0. 71 ) mmol/L], and between case group B and control group B [ (4. 4±0. 8) mmol/L and (4. 5±0. 7) mmol/L]. The levels of serum phosphorus in case group A and B [ (1.01 ± 0. 22) mmol/L and (0. 89 ± 0. 18 ) mmol/L] were significantly lower than in control group A and B [ ( 1.23 ± 0. 24) mmol/L and ( 1.10 ±0. 13 ) mmol/L ] , respectively. But the levels of serum calcium had no significant difference between case group A and control group A [ (2. 39 ± 0. 23 ) mmol/and (2.41 ± 0. 12) mmol/L], and between case group B and control group B [(2.40 ± 0.28) mmol/L and (2. 42 ±0. 20) mmol/L]. Conclusion The abnormal metabolism of lipid and phosphorus, and the higher levels of serum P may playing a role in the pathogenesis of endometriosis.
