国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2011年
11期
748-751
,共4页
血管内皮生长因子%甲状腺肿瘤%淋巴转移%治疗
血管內皮生長因子%甲狀腺腫瘤%淋巴轉移%治療
혈관내피생장인자%갑상선종류%림파전이%치료
Vascular endothelial growth factor%Thyroid neoplasms%Lymphatic metastasis%Therapy
血管内皮生长因子特异性作用于血管内皮细胞,通过促进内皮细胞的增生,增加血管通透性,以诱导肿瘤血管及淋巴管生成,在肿瘤的发生发展中起到关键作用.研究表明,VEGF及其受体的表达与甲状腺癌的发生,淋巴结转移,预后密切相关,抑制VEGF及其受体的表达在甲状腺未分化癌及髓样癌的治疗中有一定的应用前景.
血管內皮生長因子特異性作用于血管內皮細胞,通過促進內皮細胞的增生,增加血管通透性,以誘導腫瘤血管及淋巴管生成,在腫瘤的髮生髮展中起到關鍵作用.研究錶明,VEGF及其受體的錶達與甲狀腺癌的髮生,淋巴結轉移,預後密切相關,抑製VEGF及其受體的錶達在甲狀腺未分化癌及髓樣癌的治療中有一定的應用前景.
혈관내피생장인자특이성작용우혈관내피세포,통과촉진내피세포적증생,증가혈관통투성,이유도종류혈관급림파관생성,재종류적발생발전중기도관건작용.연구표명,VEGF급기수체적표체여갑상선암적발생,림파결전이,예후밀절상관,억제VEGF급기수체적표체재갑상선미분화암급수양암적치료중유일정적응용전경.
Vascular endothelial growth factor (VEGF)-specific effects on vascular endothelial cells,by promoting endothelial cell proliferation,increased vascular permeability,to induce tumor angiogenesis and lymphangiogenesis in tumor development has played key role.Studies have shown,VEGF and its receptor expression and the incidence of thyroid cancer,lymph node metastasis,prognosis,inhibition of VEGF and its receptor expression in anaplastic thyroid cancer and medullary cancer treatment in a certain application.
