CAJ | 학술논문

目的观察西妥昔单抗联合化疗在治疗大肠癌肝转移中的疗效.方法 8例失去手术机会或不愿手术的大肠癌肝转移患者,应用西妥昔单抗(cetuximab)联合化疗,以治疗后肝脏CT、肿瘤标记物评价疗效.结果 8例全部按计划完成治疗,西妥昔单抗联合化疗近期有效率为62%,肝转移灶有不同程度的缩小或消失,其中肝转移灶完全消失(CR)1例,缩小(PR)6例,稳定(SD)1例,增大(PD)0例,所有病例肿瘤标记物均有不同程度下降.结论西妥昔单抗联合化疗能提高大肠癌肝转移化疗的疗效.
목적 관찰서타석단항연합화료재치료대장암간전이중적료효.방법 8례실거수술궤회혹불원수술적대장암간전이환자,응용서타석단항(cetuximab)연합화료,이치료후간장CT、종류표기물평개료효.결과 8례전부안계화완성치료,서타석단항연합화료근기유효솔위62%,간전이조유불동정도적축소혹소실,기중간전이조완전소실(CR)1례,축소(PR)6례,은정(SD)1례,증대(PD)0례,소유병례종류표기물균유불동정도하강.결론 서타석단항연합화료능제고대장암간전이화료적료효.
Objective To observe the effect of cetuximab combined with chemotherapy in liver metastasis of colorectal carcinoma. Methods Eight patients with liver metastasis of colorectal carcinoma, who lost the opportunity of operation or not willing to operate, treated by cetuximab combined with chemotherapy. Therapeutic effect was evaluated with liver CT and tumor marker. Results Eight patients all underwent therapy as planned. The efficacy in the near future was 62%. Liver metastasis decreased or disappeared in different degree, CR one patient, PR six patients, SD one patient and PD zero. Tumor marker also decreased in different degree. Conclusion Cetuximab can enhance the chemotherapeutic efficacy on liver metastasis of colorectal cracinoma.