时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2009年
11期
2681-2682
,共2页
王亮%丁里玉%丁芳%李春香%朱晓卉%郝蕾
王亮%丁裏玉%丁芳%李春香%硃曉卉%郝蕾
왕량%정리옥%정방%리춘향%주효훼%학뢰
竹叶%关木通%配伍%马兜铃酸A%肾毒性
竹葉%關木通%配伍%馬兜鈴痠A%腎毒性
죽협%관목통%배오%마두령산A%신독성
Bamboo leaf%Aristolochiae manshuriensis%Compatibility%Aristolochic Acid A%Nephrotoxicity
目的 观察不同剂量竹叶对关木通中马兜铃酸A溶出量的影响.方法 采用反相高效液相色谱法测定不同剂量竹叶配伍关木通中马兜铃酸A的溶出量.结果 关木通马兜铃酸A溶出量为0.106 mg/ml;竹叶与关木通1∶4配伍其溶出量为0.041 mg/ml.结论 中药竹叶可明显降低关木通马兜铃酸A溶出量61%;竹叶与关木通以1∶4配比对其马兜铃酸A的溶出量降低最明显.
目的 觀察不同劑量竹葉對關木通中馬兜鈴痠A溶齣量的影響.方法 採用反相高效液相色譜法測定不同劑量竹葉配伍關木通中馬兜鈴痠A的溶齣量.結果 關木通馬兜鈴痠A溶齣量為0.106 mg/ml;竹葉與關木通1∶4配伍其溶齣量為0.041 mg/ml.結論 中藥竹葉可明顯降低關木通馬兜鈴痠A溶齣量61%;竹葉與關木通以1∶4配比對其馬兜鈴痠A的溶齣量降低最明顯.
목적 관찰불동제량죽협대관목통중마두령산A용출량적영향.방법 채용반상고효액상색보법측정불동제량죽협배오관목통중마두령산A적용출량.결과 관목통마두령산A용출량위0.106 mg/ml;죽협여관목통1∶4배오기용출량위0.041 mg/ml.결론 중약죽협가명현강저관목통마두령산A용출량61%;죽협여관목통이1∶4배비대기마두령산A적용출량강저최명현.
Objective To observe the effects of the dissolution of aristolochic acid A in Aristolochiae manshuriensis by different doses of bamboo leaf. Methods The dissolution of aristolochic acid A in different dose bamboo leaf mixed with Aristolochiae manshuriensis was determined by RP - HPLC. Results ①The dissolution of aristolochic acid A was 0.106 mg/ml in aristolochiae manshuriensis.②The dissolution of aristolochic acid A was 0.041 mg/ml in bamboo leaf mixed with Aristolochiae manshuriensis (the ratio of bamboo leaf and Aristolochiae manshuriensis was 1:4 ). Conclusion ①Bamboo leaf can obviously reduce the dissolution of aristolochic acid A to 61 %.②When the ratio of bamboo leaf and Aristolochiae manshuriensis is 1:4, the reduction of dissolution of aristolochic acid A is the most significant.
