CAJ | 학술논문

利用冷冻塑形法制备了具有定向孔隙结构的大孔磷酸钙骨水泥支架.利用扫描电镜(scanning electron microscope,SEM)和x射线衍射(X-ray diffraction,XRD)对材料的孔隙结构和物相进行了研究.SEM照片显示:多孔磷酸钙骨水泥具有与冰晶生长方向一致的相互连通的大孔.开口大孔的尺寸在径向能达到150～200 μm,在轴向能达到500～1 000 μm.孔隙的大小可以通过改变冷冻参数进行调节.XRD谱显示:多孔磷酸钙骨水泥中的主要相为弱结晶的羟基磷灰石.材料的孔隙率可以通过调整液固比在70%到90%之间进行调节.实验制备的大孔磷酸钙骨水泥支架是很有希望的骨组织工程支架材料.
이용냉동소형법제비료구유정향공극결구적대공린산개골수니지가.이용소묘전경(scanning electron microscope,SEM)화x사선연사(X-ray diffraction,XRD)대재료적공극결구화물상진행료연구.SEM조편현시:다공린산개골수니구유여빙정생장방향일치적상호련통적대공.개구대공적척촌재경향능체도150～200 μm,재축향능체도500～1 000 μm.공극적대소가이통과개변냉동삼수진행조절.XRD보현시:다공린산개골수니중적주요상위약결정적간기린회석.재료적공극솔가이통과조정액고비재70%도90%지간진행조절.실험제비적대공린산개골수니지가시흔유희망적골조직공정지가재료.
A macroporous calcium phosphate cement scaffold with oriented pore structure is prepared by freeze casting. The pore structure and phases formed were evaluated by scanning electron microscope(SEM)and X-ray diffraction (XRD). The photographs of SEM show that the porous calcium phosphate cements have interconnected macropores aligned along the ice growth direction and the sizes of the open interconnected macropores can reach 150μm and 200 μm in their radial dimension and 500-1 000 μmn in the axial one. The pore size could be adjusted by the freezing parameters to match the requirements for bone tissue. The XRD patterns of the specimens show that poorly crystallized hydroxyapatite (HA) was the main phase present in the porous calcium phosphate cement.The porosity of the samples could be regulated from about 70% to 90% by the adjustment of the initial liquid to powder mass ratio.The macroporous calcium phosphate cement prepared in this work might be a potential scaffold for bone tissue engineering.