CAJ | 학술논문

雌性生殖道内适宜的液体微环境对一系列生殖事件起至关重要的作用.位于生殖道上皮细胞顶膜或基底膜的一系列离子通道和转运体,通过对水、电解质的跨膜转运,从而调节雌性生殖道内液体的分泌与吸收.本综述着重探讨了上皮细胞钠离子通道和囊性纤维化跨膜电导调节体对雌性生殖道内液体容量和成分的调节以及它们在不同生殖事件,比如精子获能及着床中的重要作用.同时对因离子通道失活或失调引起的雌性生殖道内液体微环境稳态失衡导致的一系列病理改变,如卵巢过度刺激综合征、输卵管积水以及不孕提出了新的见解.
자성생식도내괄의적액체미배경대일계렬생식사건기지관중요적작용.위우생식도상피세포정막혹기저막적일계렬리자통도화전운체,통과대수、전해질적과막전운,종이조절자성생식도내액체적분비여흡수.본종술착중탐토료상피세포납리자통도화낭성섬유화과막전도조절체대자성생식도내액체용량화성분적조절이급타문재불동생식사건,비여정자획능급착상중적중요작용.동시대인리자통도실활혹실조인기적자성생식도내액체미배경은태실형도치적일계렬병리개변,여란소과도자격종합정、수란관적수이급불잉제출료신적견해.
An optimal fluid microenvironment in the female reproductive tract is considered to be crucial for successful reproductive events. Fluid absorption and secretion across the reproductive tract epithelia largely depends on electrolyte transport through the apically and basolaterally located ion channels, working together with an array of other transporters. This review will discuss the role of epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) in regulating the fluid volume and composition of the reproductive tract and their importance in various reproductive events such as sperm capacitation and implantation. Disturbance of the fluid microenvironment due to defects or abnormal regulation of these ion channels as causes for a number of pathological conditions, such as ovarian hyperstimulation syndromes, hydrosalpinx and infertility, is also discussed.