药学学报
藥學學報
약학학보
ACTA PHARMACEUTICA SINICA
2001年
5期
351-355
,共5页
紫花前胡%紫花前胡素D%紫花前胡素F
紫花前鬍%紫花前鬍素D%紫花前鬍素F
자화전호%자화전호소D%자화전호소F
目的研究中药紫花前胡［Peucedanum decursivum (Miq.) Maxim］根的化学成分。方法用硅胶柱色谱和制备型高效液相色谱进行分离纯化，用光谱分析和化学方法鉴定其结构。结果从紫花前胡根中分得7个线型吡喃香豆素类化合物，其结构分别鉴定为3′(S)-hydroxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (1); 3′(S)-acetoxy-4′(R)-hydroxy-3′,4′-dihydroxanthyletin (2); 3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (3); Pd-C-IV (4); Pd-C-II (5); (+)-3′S-Decursinol (6); (+)-trans-Decursidinol (7)。结论化合物1和2为新化合物，分别命名为紫花前胡素D和紫花前胡素F;6和7为首次从该植物中分得。
目的研究中藥紫花前鬍［Peucedanum decursivum (Miq.) Maxim］根的化學成分。方法用硅膠柱色譜和製備型高效液相色譜進行分離純化，用光譜分析和化學方法鑒定其結構。結果從紫花前鬍根中分得7箇線型吡喃香豆素類化閤物，其結構分彆鑒定為3′(S)-hydroxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (1); 3′(S)-acetoxy-4′(R)-hydroxy-3′,4′-dihydroxanthyletin (2); 3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (3); Pd-C-IV (4); Pd-C-II (5); (+)-3′S-Decursinol (6); (+)-trans-Decursidinol (7)。結論化閤物1和2為新化閤物，分彆命名為紫花前鬍素D和紫花前鬍素F;6和7為首次從該植物中分得。
목적연구중약자화전호［Peucedanum decursivum (Miq.) Maxim］근적화학성분。방법용규효주색보화제비형고효액상색보진행분리순화，용광보분석화화학방법감정기결구。결과종자화전호근중분득7개선형필남향두소류화합물，기결구분별감정위3′(S)-hydroxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (1); 3′(S)-acetoxy-4′(R)-hydroxy-3′,4′-dihydroxanthyletin (2); 3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (3); Pd-C-IV (4); Pd-C-II (5); (+)-3′S-Decursinol (6); (+)-trans-Decursidinol (7)。결론화합물1화2위신화합물，분별명명위자화전호소D화자화전호소F;6화7위수차종해식물중분득。
AIM To study the chemical constituents of Peucedanum decursivum. METHODS Various column chromatographies with silica gel and HPLC were employed for the isolation and purification. The structures of the compounds were elucidated on basis of spectral analyses and chemical methods. RESULTS Seven compounds were isolated from the roots of Peucedanum decursivum (Miq.) Maxim. 1 is 3′(S)-hydroxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin, named Decursitin D; 2 is 3′(S)-acetoxy-4′(R)-hydroxy-3′,4′-dihydroxanthyletin, named decursitin F; the others are 3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin (3), Pd-C-IV (4), Pd-C-II (5), (+)-3′S-decursinol (6) and (+)-trans-decursidinol (7). CONCLUSION Compounds 1 and 2 are new compounds, while compounds 6 and 7 were isolated from Peucedanum decursivum (Miq.) Maxim for the first time.
