CAJ | 학술논문

Objective In this double-blind randomized trial, we compare the effect of 75 mg mifeprostone in capsules on termination of early pregnancy was compared with that of 150 mg in tablets combined with misoprostol. Methods A total of 160 patients were randomly divided into two groups with 80 for each group. The capsule group was administered with mifeprostone 75 mg in capsules,placebo tablets and misoprostol 0. 6 mg. The tablet group was administered with mifeprostone 150 mg in tablets, placebo capsules and misoprostol 0. 6 mg.Results The complete abortion rate in the capsule group and in the tablet group was 98. 8% and 97. 5% respectively, with no significant difference (P＞ 0. 05). There were no significant differences in bleeding time after abortion, side effects, recovery of menstruation or length of menstrual period between the two groups.Conclusion The clinical effect of mifeprostone capsule is the same with that of tablet in combination with misoprostol in terminating early pregnancy, while dose and cost is lower and the side effect is smaller. Mi feprostone capsule is recommended to be widely used for terminating early pregnancy.