CAJ | 학술논문

应用PCR-SSO基因分型技术，对我国云南西部地区3代内无血缘关系的76个彝族健康个体进行了HLA-DQB1位点的基因分型。结果显示，在DQB1的38个等位基因中，观察到13个等位基因。云南西部彝族表现为DQB10301（36.18%～36.84%）最常见。其他频率大于5%的等位基因还有DQB10502（10.53%～11.18%）、DQB10401（9.21%）、DQB10302（8.55%～9.21%）、DQB10601（7.89%）、DQB105031（6.58%）、DQB103032（5.92%～6.58%）。和其他13个华人群体DQB1等位基因的频率比较分析表明，总体上，云南西部彝族和其他各华人群体间都存在很大的差异。显示其HLA等位基因频率分布的民族独特性。
응용PCR-SSO기인분형기술，대아국운남서부지구3대내무혈연관계적76개이족건강개체진행료HLA-DQB1위점적기인분형。결과현시，재DQB1적38개등위기인중，관찰도13개등위기인。운남서부이족표현위DQB10301（36.18%～36.84%）최상견。기타빈솔대우5%적등위기인환유DQB10502（10.53%～11.18%）、DQB10401（9.21%）、DQB10302（8.55%～9.21%）、DQB10601（7.89%）、DQB105031（6.58%）、DQB103032（5.92%～6.58%）。화기타13개화인군체DQB1등위기인적빈솔비교분석표명，총체상，운남서부이족화기타각화인군체간도존재흔대적차이。현시기HLA등위기인빈솔분포적민족독특성。
HLA-DQB1 genes from 76 individuals of Yichu ethnic group in Yunnan Province were investigated, using PCR-SSO genotyping method. Of the 38 DQB1 alleles detected, DQB10301 (gene frequency: 36.18%～36.84%) was the most common gene. The frequencies of DQB10502(10.53%～11.18%), DQB10401(9.21%), DQB10302(8.55%～9.21%), DQB10601(7.89%), DQB105031(6.58%), andDQB103032(5.92%～6.58%)aremorethan5%.WhileDQB10504,DQB10604,DQB106052,DQB10606,DQB10607,DQB10608,DQB106112, DQB10613, DQB10615, DQB10203, DQB10305, DQB10306, DQB10307, and DQB10308 were not observed. Comparison of HLA-DQB1 allele frequencies of Yichu with those of 13 other Chinese ethnic groups showed some significant differences, suggesting Yichu is unique in the distribution of HLA alleles.