CAJ | 학술논문

探讨内皮素(ET)在蛛网膜下腔出血(SAH)发生发展中的作用。方法：采用放射免疫分析法检测36例SAH患者血浆ET浓度。结果：①SAH组ET含量为(127.45±11.30)ng/L，明显高于对照组的(66.75±7.23)ng/L(P<0.001)；②血浆ET浓度动态变化规律：发病24h内开始升高，半月内持续偏高(4～7d达高峰)，之后下降，发病1月后恢复正常，与SAH后脑血管痉挛(CVS)的时程相一致；③有症状性血管痉挛者ET含量为(166.42±12.12)ng/L明显高于无症状性血管痉挛者的(96.86±10.08)ng/L(P<0.001)；④血浆ET浓度与病情轻重及是否合并其他脏器损害有关：重型为(161.63±12.80)ng/L，明显高于轻型的(99.96±6.08)ng/L(P<0.001)；合并其他脏器损害者为(155.33±11.15)ng/L明显高于单纯SAH的(103.05±12.53)ng/L(P<0.001)。结论：内皮素在SAH的发生发展尤其是在SAH后的CVS中起着重要的作用，测定其浓度有助于判断病情预后。
탐토내피소(ET)재주망막하강출혈(SAH)발생발전중적작용。방법：채용방사면역 분석법검측36례SAH환자혈장ET농도。결과：①SAH조ET함량위(127.45±11.30)ng/L，명현고우대조조적(66.75±7.23)ng/L(P<0.001)；②혈장ET농도동태변화규률：발병24h내개시승고，반월내지속편고(4～7d체고봉)，지후하강，발병1월후회복정상，여SAH후뇌혈관경련(CVS)적시정상일치；③유증상성혈관경련자ET함량위(166.42±12.12)ng/L명현고우무증상성혈관경련자적(96.86±10.08)ng/L(P<0.001)；④혈장ET농도여병정경중급시부합병기타장기손해유관：중형위(161.63±12.80)ng/L，명현고우경형적(99.96±6.08)ng/L(P<0.001)；합병기타장기손해자위(155.33±11.15)ng/L명현고우단순SAH적(103.05±12.53)ng/L(P<0.001)。결론：내피소재SAH적발생발전우기시재SAH후적CVS중기착중요적작용，측정기농도유조우판단병정예후。
To investigate the role of enothelin (ET) in patients with subarachnoid hemorrhage(SAH). Methods:The changes of ET in plasma of 36 patients with SAH was observed by radioimmunoassay. Results: ①The levels of ET in SAH group[(127.45±11.30)ng/L] were higher than those of normal group [(66.75±7.23)ng/L] significantly(P<0.001). ②The levels of ET in SAH group elevated in 24 hours, and lasted for 15d(reaching the peak during 4～7d),then began to descend and recovered to normal level 30d later after the onset of SAH.③The levels of ET in SAH with cerebral vasospasm(CVS)〔(166.42±12.12)ng/L〕were significantly higher than those of without CVS 〔(96.86±10.08)ng/L〕(P<0.001). Conclusion: ET plays a key role in the pathogenesis of SAH and can be used as an important prognosis indicator