CAJ | 학술논문

观察左旋18甲基炔诺酮（LNG）和低剂量米非司酮（Ru486）用紧急避孕的有效性及可接受性。采用双盲随机比较方法吸收合格妇女100例，在一次无防护性交后72 h内随机进入LNG组（50例）和Ru486组（50例）进行治疗。LNG组首次服用LNG0.75 mg，12 h重复1次；Ru486组首次服用Ru486 10 mg，12 h服安慰剂一片，于预期下次月经日期的第7d进行随访，以了解避孕有效性及副反应。结果：LNG组发生1例妊娠，失败率为2%。Ru486组无妊娠发生。避孕有效率两组分别为77.8%和100%（P<0.05），有统计学差异。副反应发生率两组均在10%以内，且很轻微，月经正常者依次为90%和88%，结果证实左旋18甲基炔诺酮和低剂量米非司酮用于紧急避孕是安全有效的。
관찰좌선18갑기결낙동（LNG）화저제량미비사동（Ru486）용긴급피잉적유효성급가접수성。채용쌍맹수궤비교방법흡수합격부녀100례，재일차무방호성교후72 h내수궤진입LNG조（50례）화Ru486조（50례）진행치료。LNG조수차복용LNG0.75 mg，12 h중복1차；Ru486조수차복용Ru486 10 mg，12 h복안위제일편，우예기하차월경일기적제7d진행수방，이료해피잉유효성급부반응。결과：LNG조발생1례임신，실패솔위2%。Ru486조무임신발생。피잉유효솔량조분별위77.8%화100%（P<0.05），유통계학차이。부반응발생솔량조균재10%이내，차흔경미，월경정상자의차위90%화88%，결과증실좌선18갑기결낙동화저제량미비사동용우긴급피잉시안전유효적。
The efficacy，side effects and acceptability of levonorgestrel (LNG) and low dose mifepristone (RU486) in emergency contraception were compared. In a randomized double-blind comparative trial，a total of 100 health women with unprotected intercourse within 72 h were allocated to one of the two experimental groups. In the LNG group，0.75 mg LNG was taken twice in an interval of 12 h，while in the Ru486 group a single dose of 10 mg Ru486 was taken and placebo after 12 h. Follow-up visit was carried out on the 7th day of the expected next menstruation to evaluate the contraceptive efficacy and side effects. Results showed that in the LNG group 1 pregnancy occurred among 50 women with the use failure rate being 2 %，while in the Ru486 group no pregnancy occurred among 50 women. Contraceptive efficacy rate of preventing pregnancy was 77.8 % and 100 % respectively，with the difference being statistically significant (P<0.05). The incidence of various side effects，which were mild，was less than 10 %. Normal menstruation in LNG group and Ru486 group was 90 % and 88 % respectively without statistical difference between the two groups. It was concluded that the use of levonorgestrel or low dose mifepristone for emergency contraception was effective and safe.