CAJ | 학술논문

目的：探讨S-100蛋白检测与喉癌的生物学行为及预后的关系。方法：采用免疫组化方法以抗S-100蛋白抗体标记68例喉癌组织和21例非喉癌组织中S-100蛋白阳性细胞。结果：68例喉癌组织中S-100蛋白细胞阳性检出率为63.24%，主要散在于肿瘤细胞间和间质中，非喉癌组织中很少见到S-100蛋白细胞阳性，它的分布情况与喉癌预后有关；S-100蛋白阳性者术后5年生存率(68.73%)明显高于阴性者(39.32%)，P＜0.05。结论：喉癌组织中出现S-100蛋白阳性细胞者预后好，在临床上，S-100蛋白细胞的检测对判断喉癌预后有一定参考价值。
목적：탐토S-100단백검측여후암적생물학행위급예후적관계。방법：채용면역조화방법이항S-100단백항체표기68례후암조직화21례비후암조직중S-100단백양성세포。결과：68례후암조직중S-100단백세포양성검출솔위63.24%，주요산재우종류세포간화간질중，비후암조직중흔소견도S-100단백세포양성，타적분포정황여후암예후유관；S-100단백양성자술후5년생존솔(68.73%)명현고우음성자(39.32%)，P＜0.05。결론：후암조직중출현S-100단백양성세포자예후호，재림상상，S-100단백세포적검측대판단후암예후유일정삼고개치。
Objective:To study the relationship between S-100 protein and prognosis of laryngeal carcinoma.Method:S-100 protein was observed by immunohistochemical methods using anti-S-100 protein antibody in 68 laryngeal carcinoma and 21 non-cancer laryngeal tissues.Result:The result showed that S-100 protein positive were found 43(63.24%)in 68 laryngeal carcinoma.S-100 protein positive cells were interspersed among the tumor cells and in the stroma.S-100 protein were rare in non-cancer laryngeal tissues.The five-year survival rate in patients with S-100 protein positive was significantly higher than that in patients with S-100 protein negative.Conclusion:Our result indicated that the detection of S-100 protein is of value for the prognostic analysis in patients with laryngeal carcinoma.