CAJ | 학술논문

目的了解巨细胞病毒肝炎(CMV-IgM抗体阳性)和丙型肝炎(HCV-IgM抗体阳性)1～6月的婴儿患者血清中某些炎性介质的异常变化.方法应用ELISA法和硝酸还原酶法,分别检测了56例CMV抗体和67例HCV抗体阳性婴儿肝炎综合征(婴肝)患儿及正常对照组58例小儿的血清干扰素α (IFN-α),白细胞介素-8(IL-8),肿瘤坏死因子-α (TNF-α)和一氧化氮(NO)的含量.结果正常对照组58例血清IFN-α,IL-8,TNF-α,NO含量分别为226.74±73.82 ng/L,13.24±5.36 ng/L,217.14±76.30 ng/L,25.98±8.70 μmol/L.CMV抗体阳性婴肝组血清IFN-α,IL-8,TNF-α和NO的含量分别为582.26±131.72 ng/L,75.28±33.57 ng/L,429.46±156.32 ng/L和59.87±16.42 μmol/L,明显高于正常对照组(P<0.01);HCV抗体阳性婴肝组上述四项指标含量分别为558.32±114.64 ng/L,71.34±27.64 ng/L,374.35±138.4 ng/L和62.24±21.38 μmol/L,其含量亦明显高于正常对照组(P<0.001).CMV与HCV抗体阳性婴肝组比较,无明显差异(P>0.05).TNF-α和NO在这两组婴肝中分别呈正相关(r1 =0.62,r2 =0.57,P<0.01).结论 CMV和HCV抗体阳性婴肝急性期患儿,血清TNF-α,IL-8,IFN-α和NO明显增高.
목적료해거세포병독간염(CMV-IgM항체양성)화병형간염(HCV-IgM항체양성)1～6월적영인환자혈청중모사염성개질적이상변화.방법응용ELISA법화초산환원매법,분별검측료56례CMV항체화67례HCV항체양성영인간염종합정(영간)환인급정상대조조58례소인적혈청간우소α (IFN-α),백세포개소-8(IL-8),종류배사인자-α (TNF-α)화일양화담(NO)적함량.결과정상대조조58례혈청IFN-α,IL-8,TNF-α,NO함량분별위226.74±73.82 ng/L,13.24±5.36 ng/L,217.14±76.30 ng/L,25.98±8.70 μmol/L.CMV항체양성영간조혈청IFN-α,IL-8,TNF-α화NO적함량분별위582.26±131.72 ng/L,75.28±33.57 ng/L,429.46±156.32 ng/L화59.87±16.42 μmol/L,명현고우정상대조조(P<0.01);HCV항체양성영간조상술사항지표함량분별위558.32±114.64 ng/L,71.34±27.64 ng/L,374.35±138.4 ng/L화62.24±21.38 μmol/L,기함량역명현고우정상대조조(P<0.001).CMV여HCV항체양성영간조비교,무명현차이(P>0.05).TNF-α화NO재저량조영간중분별정정상관(r1 =0.62,r2 =0.57,P<0.01).결론 CMV화HCV항체양성영간급성기환인,혈청TNF-α,IL-8,IFN-α화NO명현증고.