CAJ | 학술논문

目的:观察氟哌啶醇季铵盐衍生物对冠状动脉的作用.方法:利用氟哌啶醇所致小鼠锥体外系不良反应模型,观察其衍生物(F3)的作用;利用猪冠状动脉条生物鉴定,观察F3(10-6,10-5 and 10-4moL/L)对KCl(10～40mmoL/L)诱导的冠脉条收缩的拮抗作用,阻断由KCl(40mmoL/L)诱导的冠脉条的收缩;利用豚鼠离体心脏灌流,观察F3(10-6, 5×10-6, 10-5moL/L)拮抗脑垂体后叶素所致冠脉流量减少的作用.结果:氟哌啶醇可致小鼠产生类帕金森氏综合征,而在F3各剂量组中没有出现同样的作用.F3量效依赖地拮抗由KCl所致的冠脉条收缩,并阻断较大剂量KCl所致的冠脉条的痉挛.F3 可以量效依赖地拮抗由脑垂体后叶素引起的离体豚鼠心脏冠脉流量减少.结论:F3 引起冠状动脉的扩张,但是不引起氟哌啶醇样的锥体外系症状.
목적:관찰불고정순계안염연생물대관상동맥적작용.방법:이용불고정순소치소서추체외계불량반응모형,관찰기연생물(F3)적작용;이용저관상동맥조생물감정,관찰F3(10-6,10-5 and 10-4moL/L)대KCl(10～40mmoL/L)유도적관맥조수축적길항작용,조단유KCl(40mmoL/L)유도적관맥조적수축;이용돈서리체심장관류,관찰F3(10-6, 5×10-6, 10-5moL/L)길항뇌수체후협소소치관맥류량감소적작용.결과:불고정순가치소서산생류파금삼씨종합정,이재F3각제량조중몰유출현동양적작용.F3량효의뢰지길항유KCl소치적관맥조수축,병조단교대제량KCl소치적관맥조적경련.F3 가이량효의뢰지길항유뇌수체후협소인기적리체돈서심장관맥류량감소.결론:F3 인기관상동맥적확장,단시불인기불고정순양적추체외계증상.
Objective: To observe the effect of quaternary ammonium salt derivation of haloperidol on coronary artery. Method: By using the model of adverse reaction of extrapyramidal system induced by haloperidol ip on mice, to observe the behavior effect of its derivation(F3)on same dose and administration. Using the bioassay of porcine coronary artery strips, F3(10-6, 10-5 and 10-4moL/L)were added into the bath medium prior to KCl(10～40mmoL/L)administration to observe the effect of F3 on dose-response curve of contraction induced by KCl, and the block action of F3(10-4moL/L)on the contraction induced by KCl respectively; Using the Langendorff perfusion, to observe the effect of F3(10-6 , 5×10-6, 10-5moL/L)on reduction of coronary artery flow of guinea-pig induced by pituitrin. Results: Haloperidol induced Parkinsons like syndrome, but F3 could not induce the same effect. F3 decreased coronary artery strips contraction curve induced by KCl in dose-dependent manner. F3 also blocked the contraction induced by KCl. F3 antagonized the reduction of coronary flow induced by pituitrin on isolated heart of guinea-pig in dose-dependent manner. Conclusion: F3 caused coronary artery dilation as haloperidol , and did not cause any adverse reaction of extrapyramidal system as it.