丁丙诺啡与吗啡用于术后静脉病人自控镇痛的随机双盲研究
정병낙배여마배용우술후정맥병인자공진통적수궤쌍맹연구
A Double Blind Randomized Controlled Clinical Study of Intravenous Patient-controlled Analgesia with Buprenorphine vs Morphine in The Postoperative Patients
  • 万方数据
    中国临床药理学杂志 중국림상약이학잡지
    THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
    2003年 2期 92-95 ,共4页

    龚志毅%叶铁虎%栾秀姝%田鸣%李玉华%王芳%崔伟华%朱斌%赵文晖

    공지의%협철호%란수주%전명%리옥화%왕방%최위화%주빈%조문휘

    病人自控镇痛%丁丙诺啡%吗啡 病人自控鎮痛%丁丙諾啡%嗎啡
    병인자공진통%정병낙배%마배
    目的:评价丁丙诺啡用于妇科手术后病人自控镇痛(patient-controlled analgesia,PCA)的效应和安全性.方法:60例妇科开腹子宫切除术病人术后随机分为丁丙诺啡组(B组,n=30)和吗啡组(M组,n=30),接受PCA治疗.B组使用丁丙诺啡(每次0.03 mg),最大用量每天1.2 mg;M组使用吗啡(每次1 mg),最大用量每天40 mg.两组PCA药液中均加入氟哌啶4 mg.结果:丁丙诺啡组与吗啡组24 h总的疼痛缓解程度(totalpain relief,TPR)分别为16.9±5.9和22.2±7.4(P＞0.05),两组病人24h总的疼痛差值(sum of pain intensity differences,SPID)分别为46.5±22.0和40.0±19.1(P＜0.01).B组和M组恶心及呕吐的发生率无显著差别,分别为53.3%和50%.结论:丁丙诺啡用于妇科手术后静脉PCA的镇痛效应与吗啡相同,其恶心及呕吐的发生率接近于吗啡.
    목적:평개정병낙배용우부과수술후병인자공진통(patient-controlled analgesia,PCA)적효응화안전성.방법:60례부과개복자궁절제술병인술후수궤분위정병낙배조(B조,n=30)화마배조(M조,n=30),접수PCA치료.B조사용정병낙배(매차0.03 mg),최대용량매천1.2 mg;M조사용마배(매차1 mg),최대용량매천40 mg.량조PCA약액중균가입불고정4 mg.결과:정병낙배조여마배조24 h총적동통완해정도(totalpain relief,TPR)분별위16.9±5.9화22.2±7.4(P＞0.05),량조병인24h총적동통차치(sum of pain intensity differences,SPID)분별위46.5±22.0화40.0±19.1(P＜0.01).B조화M조악심급구토적발생솔무현저차별,분별위53.3%화50%.결론:정병낙배용우부과수술후정맥PCA적진통효응여마배상동,기악심급구토적발생솔접근우마배.
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