Effect of thermal injury on LPS-mediated Toll signaling pathways by murine peritoneal macrophages: inhibition of DNA-binding of transcription factor AP-1 and NF-кB and gene expression of c-fos and IL-12p40
  • 万方数据
    中国科学C辑(英文版) 중국과학C집(영문판)
    SCIENCE IN CHINA (Series C)
    2002年 6期 613-622 ,共10页

    王兴宇%张劲松%苏踊跃%李昌麟%冯卫国%张宗梁

    왕흥우%장경송%소용약%리창린%풍위국%장종량



    thermal injury%AP-1%NF-кB%macrophages


    Thermal injury is able to induce the immune functional inhibition in the host, but the mechanisms are largely unknown. The available evidence indicates that macrophages play an important role in immune regulations and host defenses. Thus, studies of the effect of thermal injury on macrophages are essential. Transcriptional factors of AP-1 (activator protein-1) and NF-кB (nuclear factor-кB) are critical members of signal transduction pathways. These transcriptional factors have been shown to be necessary for a variety of expressions of cytokine genes. In this investigation, the effect of thermal injury on AP-1 and NF-кB was studied using a model for the murine thermal injury. Our findings indicated that thermal injury mediated the inhibition of AP-1 and NF-кB DNA binding activities and c-fos and IL-12 p40 gene expressions in response to LPS.
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